PDF(Pubmed)
Abstract：
Acute promyelocytic leukaemia (APL) is an aggressive type of leukaemia associated with severe coagulopathy and haemorrhage. Treatment with all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) therapy is life-saving and induces excellent remission rates. However, ATRA can, on rare occasions, cause pseudotumour cerebri, which is characterised by an elevation in intracranial pressure without evidence of infection or vascular or structural abnormalities. We describe a case of pseudotumour cerebri that was precipitated by ATRA therapy. Intracranial hypertension should always be considered in patients with headaches and visual complaints with normal neuroimaging. Early identification and management are essential to preventing visual loss.
摘要：
急性早幼粒细胞白血病（APL）是一种侵袭性白血病，与严重的凝血病和出血有关。全反式维甲酸（ATRA）联合三氧化二砷（ATO）治疗可挽救生命，并可产生出色的缓解率。然而,ATRA可以,在极少数情况下,因为假性脑瘤，其特征是颅内压升高，没有感染或血管或结构异常的证据。我们描述了一例通过ATRA治疗沉淀的假性脑瘤。对于患有头痛和视觉不适且神经影像学正常的患者，应始终考虑颅内高压。早期识别和管理对于防止视力丧失至关重要。
