Abstract：
Chronic refractory osteomyelitis of the foot stands as a formidable challenge in medical care, associated with significant morbidity and escalating healthcare costs. Traditional therapeutic approaches, including surgical debridement and systemic antibiotics, often fall short, leaving patients and clinicians in search of more efficacious interventions. Hyperbaric oxygen therapy (HBOT), an innovative therapeutic modality, has recently emerged as a promising adjunct therapy, offering a beacon of hope in this therapeutic conundrum. In this groundbreaking observational study, we meticulously analyzed the experiences of 80 patients suffering from chronic refractory osteomyelitis of the foot. Following surgical debridement and tailored antibiotic therapy, each patient was treated with HBOT at 2.5 atmospheres absolute for 120 min, 5 days a week, spanning an average of 50 days. Our primary endpoints focused on complete eradication of infection, recurrence metrics, and any adverse effects linked to HBOT. Astonishingly, 68 of the 80 patients (85%) achieved a total infection clearance, maintaining this status through a mean follow-up period of 36 months, all without a single report of HBOT-induced complications. Our compelling findings advocate that HBOT, synergized with standard surgical and antibiotic regimens, can revolutionize the treatment landscape for chronic refractory osteomyelitis of the foot. Given these promising preliminary results, there\'s an imperative need for extensive research to delineate the long-term advantages and to fine-tune HBOT protocols, potentially paving the way for a new therapeutic gold standard.
摘要：
慢性难治性足部骨髓炎在医疗护理中是一个巨大的挑战，与显著的发病率和不断上升的医疗保健成本有关。传统的治疗方法，包括手术清创和全身抗生素，经常做不到，让患者和临床医生寻找更有效的干预措施。高压氧治疗（HBOT），一种创新的治疗方式，最近成为一种有前途的辅助疗法，在这个治疗难题中提供了希望的灯塔。在这项开创性的观察研究中，我们仔细分析了80例慢性难治性足部骨髓炎患者的经验。手术清创和定制抗生素治疗后，每位患者在2.5个绝对大气压下接受HBOT治疗120分钟，一周五天,平均50天。我们的主要终点集中在完全根除感染，重复度量，以及与HBOT相关的任何不利影响。令人惊讶的是，80例患者中有68例（85％）实现了完全感染清除，通过平均36个月的随访期保持这种状态，所有这些都没有HBOT引起的并发症的单一报告。我们令人信服的发现主张HBOT，与标准手术和抗生素方案协同作用，可以彻底改变足部慢性难治性骨髓炎的治疗环境。鉴于这些有希望的初步结果，迫切需要广泛的研究来描绘长期的优势并微调HBOT协议，可能为新的治疗黄金标准铺平道路。
