PDF(Pubmed)
Abstract：
Ropivacaine is the most widely used local anaesthetic for peripheral nerve blocks (PNBs). The effects of various concentrations of ropivacaine in PNB have been investigated and compared by many randomised controlled trials (RCTs). This protocol aims to identify the optimal concentration of ropivacaine for PNB in adult patients.
PubMed, EMBASE, the Cochrane library and Web of Science will be searched from their inception to 10 July 2023. RCTs that compare the analgesic effects of different concentrations of ropivacaine for PNB will be included. Retrospective studies, meta-analyses, reviews, case reports, letters, conference abstracts and paediatric studies will be excluded. The duration of analgesia will be named as the primary outcome. Secondary outcomes will include the onset time of motor and sensory blockade, postoperative pain scores, analgesic requirements over 24 hours and the incidence of adverse effects. The study selection, data extraction and quality assessment will be performed by two independent reviewers. Data processing and analysis will be performed by RevMan 5.4. The quality of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation approach.
Ethical approval is not applicable. The results of this study will be submitted to peer-reviewed journals.
CRD42023406362.
PubMed, EMBASE, the Cochrane library and Web of Science will be searched from their inception to 10 July 2023. RCTs that compare the analgesic effects of different concentrations of ropivacaine for PNB will be included. Retrospective studies, meta-analyses, reviews, case reports, letters, conference abstracts and paediatric studies will be excluded. The duration of analgesia will be named as the primary outcome. Secondary outcomes will include the onset time of motor and sensory blockade, postoperative pain scores, analgesic requirements over 24 hours and the incidence of adverse effects. The study selection, data extraction and quality assessment will be performed by two independent reviewers. Data processing and analysis will be performed by RevMan 5.4. The quality of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation approach.
Ethical approval is not applicable. The results of this study will be submitted to peer-reviewed journals.
CRD42023406362.
摘要：
背景：罗哌卡因是用于周围神经阻滞（PNBs）的最广泛使用的局部麻醉剂。已通过许多随机对照试验（RCTs）研究并比较了各种浓度的罗哌卡因在PNB中的作用。该协议旨在确定成人患者中PNB的罗哌卡因的最佳浓度。
方法：PubMed，EMBASE,Cochrane图书馆和WebofScience将从成立到2023年7月10日进行搜索。将包括比较不同浓度的罗哌卡因对PNB的镇痛效果的RCT。回顾性研究,荟萃分析，reviews,病例报告,信件,会议摘要和儿科研究将被排除.镇痛的持续时间将被称为主要结果。次要结果将包括运动和感觉阻滞的开始时间，术后疼痛评分,24小时以上的镇痛需求和不良反应的发生率。研究的选择，数据提取和质量评估将由两名独立审核员进行。数据处理和分析将由RevMan5.4进行。证据的质量将通过建议分级评估来评估，开发和评估方法。
背景：道德批准不适用。这项研究的结果将提交给同行评审的期刊。
■CRD42023406362。
方法：PubMed，EMBASE,Cochrane图书馆和WebofScience将从成立到2023年7月10日进行搜索。将包括比较不同浓度的罗哌卡因对PNB的镇痛效果的RCT。回顾性研究,荟萃分析，reviews,病例报告,信件,会议摘要和儿科研究将被排除.镇痛的持续时间将被称为主要结果。次要结果将包括运动和感觉阻滞的开始时间，术后疼痛评分,24小时以上的镇痛需求和不良反应的发生率。研究的选择，数据提取和质量评估将由两名独立审核员进行。数据处理和分析将由RevMan5.4进行。证据的质量将通过建议分级评估来评估，开发和评估方法。
背景：道德批准不适用。这项研究的结果将提交给同行评审的期刊。
■CRD42023406362。
