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Abstract：
OBJECTIVE: Focal liver lesion (FLL) is a prevalent finding in cross-sectional imaging, and distinguishing between benign and malignant FLLs is crucial for liver health management. While shear wave elastography (SWE) serves as a conventional quantitative ultrasound tool for evaluating FLLs, ultrasound tissue scatterer distribution imaging (TSI) emerges as a novel technique, employing the Nakagami statistical distribution parameter to estimate backscattered statistics for tissue characterization. In this prospective study, we explored the potential of TSI in characterizing FLLs and evaluated its diagnostic efficacy with that of SWE.
METHODS: A total of 235 participants (265 FLLs; the study group) were enrolled to undergo abdominal examinations, which included data acquisition from B-mode, SWE, and raw radiofrequency data for TSI construction. The area under the receiver operating characteristic curve (AUROC) was used to evaluate performance. A dataset of 20 patients (20 FLLs; the validation group) was additionally acquired to further evaluate the efficacy of the TSI cutoff value in FLL characterization.
RESULTS: In the study group, our findings revealed that while SWE achieved a success rate of 49.43 % in FLL measurements, TSI boasted a success rate of 100 %. In cases where SWE was effectively implemented, the AUROCs for characterizing FLLs using SWE and TSI stood at 0.84 and 0.83, respectively. For instances where SWE imaging failed, TSI achieved an AUROC of 0.78. Considering all cases, TSI presented an overall AUROC of 0.81. There was no statistically significant difference in AUROC values between TSI and SWE (p > 0.05). In the validation group, using a TSI cutoff value of 0.67, the AUROC for characterizing FLLs was 0.80.
CONCLUSIONS: In conclusion, ultrasound TSI holds promise as a supplementary diagnostic tool to SWE for characterizing FLLs.
METHODS: A total of 235 participants (265 FLLs; the study group) were enrolled to undergo abdominal examinations, which included data acquisition from B-mode, SWE, and raw radiofrequency data for TSI construction. The area under the receiver operating characteristic curve (AUROC) was used to evaluate performance. A dataset of 20 patients (20 FLLs; the validation group) was additionally acquired to further evaluate the efficacy of the TSI cutoff value in FLL characterization.
RESULTS: In the study group, our findings revealed that while SWE achieved a success rate of 49.43 % in FLL measurements, TSI boasted a success rate of 100 %. In cases where SWE was effectively implemented, the AUROCs for characterizing FLLs using SWE and TSI stood at 0.84 and 0.83, respectively. For instances where SWE imaging failed, TSI achieved an AUROC of 0.78. Considering all cases, TSI presented an overall AUROC of 0.81. There was no statistically significant difference in AUROC values between TSI and SWE (p > 0.05). In the validation group, using a TSI cutoff value of 0.67, the AUROC for characterizing FLLs was 0.80.
CONCLUSIONS: In conclusion, ultrasound TSI holds promise as a supplementary diagnostic tool to SWE for characterizing FLLs.
摘要：
目的：肝脏局灶性病变（FLL）是横断面成像中的一个普遍发现，区分良性和恶性FLL对于肝脏健康管理至关重要。而剪切波弹性成像（SWE）作为常规的定量超声工具用于评估FLL，超声组织散射体分布成像（TSI）作为一种新技术，使用Nakagami统计分布参数来估计用于组织表征的反向散射统计量。在这项前瞻性研究中，我们探索了TSI在表征FLL方面的潜力,并评估了其与SWE的诊断效能.
方法：共纳入235名参与者（265名FLL；研究组）进行腹部检查，其中包括来自B模式的数据采集，SWE,和TSI建设的原始射频数据。接收器工作特征曲线下面积(AUROC)用于评估性能。另外获得20名患者(20个FLL;验证组)的数据集以进一步评估TSI截断值在FLL表征中的功效。
结果：在研究组中，我们的研究结果表明，虽然SWE在FLL测量中取得了49.43%的成功率，TSI的成功率为100%。在有效实施SWE的情况下，使用SWE和TSI表征FLL的AUROC分别为0.84和0.83。对于SWE成像失败的实例，TSI获得0.78的AUROC。考虑到所有情况,TSI呈现0.81的总体AUROC。TSI和SWE之间的AUROC值无统计学差异(p>0.05)。在验证组中，使用0.67的TSI截止值,表征FLL的AUROC为0.80.
结论：结论：超声TSI有望作为SWE表征FLL的补充诊断工具。
方法：共纳入235名参与者（265名FLL；研究组）进行腹部检查，其中包括来自B模式的数据采集，SWE,和TSI建设的原始射频数据。接收器工作特征曲线下面积(AUROC)用于评估性能。另外获得20名患者(20个FLL;验证组)的数据集以进一步评估TSI截断值在FLL表征中的功效。
结果：在研究组中，我们的研究结果表明，虽然SWE在FLL测量中取得了49.43%的成功率，TSI的成功率为100%。在有效实施SWE的情况下，使用SWE和TSI表征FLL的AUROC分别为0.84和0.83。对于SWE成像失败的实例，TSI获得0.78的AUROC。考虑到所有情况,TSI呈现0.81的总体AUROC。TSI和SWE之间的AUROC值无统计学差异(p>0.05)。在验证组中，使用0.67的TSI截止值,表征FLL的AUROC为0.80.
结论：结论：超声TSI有望作为SWE表征FLL的补充诊断工具。
