METHODS: International databases such as PubMed, Scopus, ISI Web of Science, and EMBASE were searched for available articles on the effect of nanomaterials on neuronal differentiation of embryonic stem cells (up to OCTOBER 2023). After that, screening (by title, abstract, and full text), selection, and data extraction were performed. Also, quality assessment was conducted based on the STROBE checklist.
RESULTS: In total, 1507 articles were identified and assessed, and then only 29 articles were found eligible to be included. Nine studies used 0D nanomaterials, ten used 1D nanomaterials, two reported 2D nanomaterials, and eight demonstrated the application of 3D nanomaterials. The main biomaterial in studies was polymer-based composites. Three studies reported the negative effect of nanomaterials on neural differentiation.
CONCLUSIONS: Neural differentiation is crucial in neurological regenerative medicine. Nanomaterials with different characteristics, particularly those cellular regulating activities and stem cell fate, have much potential in neural tissue engineering. These findings indicate a new understanding of potential applications of physicochemical cues in nerve tissue engineering.
方法:国际数据库,如PubMed、Scopus,ISIWebofScience,和EMBASE搜索了有关纳米材料对胚胎干细胞神经元分化影响的可用文章(直到2023年10月)。之后,筛选(按标题,abstract,和全文),选择,并进行了数据提取。此外,根据STROBE检查表进行质量评估。
结果:总计,1507篇文章进行了鉴定和评估,然后只有29篇文章被发现有资格被纳入。九项研究使用了0D纳米材料,十种使用过的一维纳米材料,两种报道的二维纳米材料,八位展示了三维纳米材料的应用。研究中的主要生物材料是基于聚合物的复合材料。三项研究报道了纳米材料对神经分化的负面影响。
结论:神经分化在神经再生医学中至关重要。具有不同特性的纳米材料,特别是那些细胞调节活动和干细胞命运,在神经组织工程方面有很大的潜力。这些发现表明对物理化学线索在神经组织工程中的潜在应用有了新的理解。