Abstract：
The objective of this systematic review is to examine longitudinal associations between post-traumatic stress disorder (PTSD) and lower respiratory symptoms (LRS) specifically among responders present at the World Trade Center (WTC) site on September 11, 2001 (9/11). This group, which we refer to as \"9/11 early responders,\" appears to have particularly high rates of both mental and physical illness relative to other 9/11-exposed populations.
We performed a systematic literature review to examine associations between PTSD and LRS among 9/11 early responders in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. After a structured search of Pubmed and the Fire Department of New York (FDNY) WTC bibliography for relevant articles, we identified 4 articles commenting on associations between PTSD and LRS in this population; all 4 passed quality review and were included in our primary analysis. 10 other articles we found in our research discussed rates of PTSD and LRS, but not associations between them, in the population in question; we commented on these in a secondary analysis.
The data demonstrate that there are significant associations between PTSD and LRS among 9/11 early responders. The data also suggest that both of these phenomena are more prevalent among 9/11 early responders relative to other 9/11-exposed populations.
These findings are relevant for optimizing care for the population in question, as well as for other survivors of past and future disasters with both psychiatric and medical sequelae.
We performed a systematic literature review to examine associations between PTSD and LRS among 9/11 early responders in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. After a structured search of Pubmed and the Fire Department of New York (FDNY) WTC bibliography for relevant articles, we identified 4 articles commenting on associations between PTSD and LRS in this population; all 4 passed quality review and were included in our primary analysis. 10 other articles we found in our research discussed rates of PTSD and LRS, but not associations between them, in the population in question; we commented on these in a secondary analysis.
The data demonstrate that there are significant associations between PTSD and LRS among 9/11 early responders. The data also suggest that both of these phenomena are more prevalent among 9/11 early responders relative to other 9/11-exposed populations.
These findings are relevant for optimizing care for the population in question, as well as for other survivors of past and future disasters with both psychiatric and medical sequelae.
摘要：
目的：本系统评价的目的是研究创伤后应激障碍（PTSD）与下呼吸道症状（LRS）之间的纵向关联，特别是在2001年9月11日（9/11）在世界贸易中心（WTC）现场的反应者之间。这个群体,我们称之为“9/11早期反应者”，“相对于其他9/11暴露人群，精神和身体疾病的发病率似乎特别高。
方法：我们根据系统评价和荟萃分析（PRISMA）指南，进行了系统文献综述，以检查9/11早期反应者中PTSD与LRS之间的关联。在对Pubmed和纽约消防局(FDNY)WTC参考书目进行结构化搜索后，寻找相关文章，我们确定了4篇评论该人群中PTSD和LRS之间关联的文章;所有4篇都通过了质量审查,并被纳入我们的主要分析.我们在研究中发现的其他10篇文章讨论了PTSD和LRS的发生率，但不是他们之间的联系，在相关人群中；我们在二次分析中对这些进行了评论。
结果：数据表明，在9/11早期反应者中，PTSD和LRS之间存在显著关联。数据还表明，相对于其他9/11暴露人群，这两种现象在9/11早期反应者中更为普遍。
结论：这些发现与优化相关人群的护理有关，以及过去和未来灾难的其他幸存者，都有精神病和医学后遗症。
方法：我们根据系统评价和荟萃分析（PRISMA）指南，进行了系统文献综述，以检查9/11早期反应者中PTSD与LRS之间的关联。在对Pubmed和纽约消防局(FDNY)WTC参考书目进行结构化搜索后，寻找相关文章，我们确定了4篇评论该人群中PTSD和LRS之间关联的文章;所有4篇都通过了质量审查,并被纳入我们的主要分析.我们在研究中发现的其他10篇文章讨论了PTSD和LRS的发生率，但不是他们之间的联系，在相关人群中；我们在二次分析中对这些进行了评论。
结果：数据表明，在9/11早期反应者中，PTSD和LRS之间存在显著关联。数据还表明，相对于其他9/11暴露人群，这两种现象在9/11早期反应者中更为普遍。
结论：这些发现与优化相关人群的护理有关，以及过去和未来灾难的其他幸存者，都有精神病和医学后遗症。
