PDF(Pubmed)
Abstract：
BACKGROUND: Equine herpes virus type 1 (EHV-1) infection in horses is associated with upper respiratory disease, neurological disease, abortions, and neonatal death.
OBJECTIVE: To determine if there is an association between the level and duration of EHV-1 viremia and either abortion or equine herpesvirus myeloencephalopathy (EHM) in domesticated horses?
METHODS: A systematic review was performed searching numerous databases to identify peer reviewed reports that evaluated viremia and EHM, or viremia and abortion published before January 19, 2021. Randomized controlled trials and observational studies were assessed for risk of bias or publication quality.
RESULTS: A total of 189 unique studies were identified, of which 34 met the inclusion criteria. Thirty studies evaluated viremia and neurologic outcomes including 4 observational studies. Eight experimental studies examined viremia and abortion, which used the Ab4 and OH03 virus strains or recombinant Ab4 derivatives. Incidence rates for both EHM and abortion in experimental studies varied among the studies as did the level of evidence. Viremia was generally detectable before the onset of either EHM or abortion. Risk of bias was generally low to moderate, sample sizes were small, and multiple studies reported negative outcome data.
CONCLUSIONS: The results of this study support that viremia is regularly present before EHM or abortion occurs. However, no inferences could be made about the relationship between the occurrence of either neurological signs or abortion and the magnitude or duration of viremia.
OBJECTIVE: To determine if there is an association between the level and duration of EHV-1 viremia and either abortion or equine herpesvirus myeloencephalopathy (EHM) in domesticated horses?
METHODS: A systematic review was performed searching numerous databases to identify peer reviewed reports that evaluated viremia and EHM, or viremia and abortion published before January 19, 2021. Randomized controlled trials and observational studies were assessed for risk of bias or publication quality.
RESULTS: A total of 189 unique studies were identified, of which 34 met the inclusion criteria. Thirty studies evaluated viremia and neurologic outcomes including 4 observational studies. Eight experimental studies examined viremia and abortion, which used the Ab4 and OH03 virus strains or recombinant Ab4 derivatives. Incidence rates for both EHM and abortion in experimental studies varied among the studies as did the level of evidence. Viremia was generally detectable before the onset of either EHM or abortion. Risk of bias was generally low to moderate, sample sizes were small, and multiple studies reported negative outcome data.
CONCLUSIONS: The results of this study support that viremia is regularly present before EHM or abortion occurs. However, no inferences could be made about the relationship between the occurrence of either neurological signs or abortion and the magnitude or duration of viremia.
摘要：
背景：马疱疹病毒1型（EHV-1）感染与上呼吸道疾病有关，神经系统疾病,堕胎,新生儿死亡。
目的：为了确定驯养马中EHV-1病毒血症的水平和持续时间与流产或马疱疹病毒性脑病（EHM）之间是否存在关联？
方法：搜索大量数据库进行了系统评价，以确定评估病毒血症和EHM的同行评审报告，或病毒血症和堕胎在2021年1月19日之前发布。对随机对照试验和观察性研究的偏倚风险或发表质量进行评估。
结果：共确定了189项独特研究，其中34人符合纳入标准。30项研究评估了病毒血症和神经系统结果，包括4项观察性研究。八项实验研究检查了病毒血症和流产，其使用Ab4和OH03病毒株或重组Ab4衍生物。实验研究中EHM和流产的发生率在研究中不同，证据水平也不同。在EHM或流产发作之前通常可以检测到病毒血症。偏见的风险通常是低到中等，样本量很小，多项研究报告阴性结果数据。
结论：这项研究的结果支持病毒血症在EHM或流产发生之前是有规律的。然而,对于神经体征或流产的发生与病毒血症的程度或持续时间之间的关系，没有推论。
目的：为了确定驯养马中EHV-1病毒血症的水平和持续时间与流产或马疱疹病毒性脑病（EHM）之间是否存在关联？
方法：搜索大量数据库进行了系统评价，以确定评估病毒血症和EHM的同行评审报告，或病毒血症和堕胎在2021年1月19日之前发布。对随机对照试验和观察性研究的偏倚风险或发表质量进行评估。
结果：共确定了189项独特研究，其中34人符合纳入标准。30项研究评估了病毒血症和神经系统结果，包括4项观察性研究。八项实验研究检查了病毒血症和流产，其使用Ab4和OH03病毒株或重组Ab4衍生物。实验研究中EHM和流产的发生率在研究中不同，证据水平也不同。在EHM或流产发作之前通常可以检测到病毒血症。偏见的风险通常是低到中等，样本量很小，多项研究报告阴性结果数据。
结论：这项研究的结果支持病毒血症在EHM或流产发生之前是有规律的。然而,对于神经体征或流产的发生与病毒血症的程度或持续时间之间的关系，没有推论。
