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Abstract：
Hyaline cartilage, which is characterized by the absence of vascularization and innervation, has minimal self-repair potential in case of damage and defect formation in the chondral layer. Chondrocytes are specialized cells that ensure the synthesis of extracellular matrix components, namely type II collagen and aggregen. On their surface, they express integrins CD44, α1β1, α3β1, α5β1, α10β1, αVβ1, αVβ3, and αVβ5, which are also collagen-binding components of the extracellular matrix. This article aims to contribute to solving the problem of the possible repair of chondral defects through unique methods of tissue engineering, as well as the process of pathological events in articular cartilage. In vitro cell culture models used for hyaline cartilage repair could bring about advanced possibilities. Currently, there are several variants of the combination of natural and synthetic polymers and chondrocytes. In a three-dimensional environment, chondrocytes retain their production capacity. In the case of mesenchymal stromal cells, their favorable ability is to differentiate into a chondrogenic lineage in a three-dimensional culture.
摘要：
透明软骨,其特征是没有血管化和神经支配，在软骨层中损伤和缺陷形成的情况下具有最小的自我修复潜力。软骨细胞是确保细胞外基质成分合成的特化细胞,即II型胶原和聚集原。在他们的表面,它们表达整合素CD44，α1β1，α3β1，α5β1，α10β1，αVβ1，αVβ3和αVβ5，它们也是细胞外基质的胶原蛋白结合成分。本文旨在通过独特的组织工程方法,为解决软骨缺损修复的可能问题作出贡献,以及关节软骨病理事件的过程。用于透明软骨修复的体外细胞培养模型可以带来先进的可能性。目前,天然和合成聚合物和软骨细胞的组合有几种变体。在三维环境中，软骨细胞保留其生产能力。在间充质基质细胞的情况下，它们的有利能力是在三维培养中分化为软骨形成谱系。
