PDF(Pubmed)
Abstract：
Several risk factors, including nutritional/lifestyle ones, play a role in gastric cancer etiology. Further interactions with mental health have also been emphasized. We hypothesized that individuals with mental disorders would exhibit compromised nutrient intake, increasing their risk of gastric cancer. The state of mental health was evaluated in 82 patients with gastric cancer and 95 healthy controls using the 21-item Depression-Anxiety-Stress Scale. The participants\' dietary intakes were evaluated by a 168-item food frequency questionnaire. Based on fully adjusted logistic regressions, there was a significant association between depression (OR = 1.938, CI 95%: 1.009-3.723) and stress (OR = 2.630, CI 95%: 1.014-6.819) with increased odds of gastric cancer. According to fully adjusted multinomial regressions, vitamins A and B6, beta-carotene, and black tea decreased the odds of depression, based on comparing the control group with cases of depression, while sugar and salt increased its odds. The highest significant association was found for salt intake and anxiety in cases with present anxiety (OR = 4.899, 95% CI: 2.218-10.819), and the highest significant protective effect was found for vitamin B6 and depression in cases with present depression (OR = 0.132, 95% CI: 0.055-0.320). However, considering causal relationships and clarifying the underlying mechanisms is imperative and requires further investigation. Advising healthy dietary patterns, e.g., a Mediterranean diet rich in vitamins, minerals, and phytochemicals such as vitamin A, B6, beta-carotene, and fiber, is expected to reduce the odds of gastric cancer, possibly related to lower levels of anxiety and depression.
摘要：
几个危险因素，包括营养/生活方式，在胃癌的病因中发挥作用。还强调了与心理健康的进一步互动。我们假设患有精神障碍的人会表现出营养摄入受损，增加他们患胃癌的风险.使用21项抑郁-焦虑-应激量表对82例胃癌患者和95例健康对照者的心理健康状况进行了评估。通过168项食物频率问卷评估参与者的饮食摄入量。基于完全调整的逻辑回归，抑郁(OR=1.938,CI95%:1.009-3.723)和应激(OR=2.630,CI95%:1.014-6.819)与胃癌发生几率增加之间存在显著关联.根据完全调整的多项回归，维生素A和B6，β-胡萝卜素，红茶降低了抑郁的几率，根据对照组与抑郁症病例的比较，而糖和盐增加了几率。在存在焦虑的情况下，盐摄入量和焦虑的相关性最高（OR=4.899，95％CI：2.218-10.819）。在目前的抑郁症患者中，维生素B6和抑郁症的保护作用最高（OR=0.132，95％CI：0.055-0.320）。然而,考虑因果关系和澄清潜在机制势在必行，需要进一步调查。建议健康的饮食习惯，例如，富含维生素的地中海饮食，矿物,和植物化学物质，如维生素A，B6，β-胡萝卜素，和纤维，有望降低患胃癌的几率，可能与较低水平的焦虑和抑郁有关。
