PDF(Pubmed)
Abstract：
Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths on melanocyte biology and skin pigmentary disorders. Different VL wavelengths may impose positive or negative effects, depending on their interactions with specific chromophores, photoaging, ROS production, circadian rhythm and other photon-mediated reactions. Further in vivo and in vitro studies are required to establish the pathologic mechanisms and application principles of VL in pigmentary disorders, as well as optimal photoprotection with coverage against VL wavelengths.
摘要：
电磁辐射,特别是可见光(VL)，对人体皮肤有复杂的影响，特别是色素沉着,这在很大程度上被忽视了。在这次审查中,我们讨论了光生物学机制，病理效应,不同波长VL在黑素细胞生物学和皮肤色素性疾病中的临床应用和治疗策略。不同的VL波长可能会产生积极或消极的影响，取决于它们与特定发色团的相互作用，光老化，ROS生产，昼夜节律和其他光子介导的反应。需要进一步的体内和体外研究，以建立VL在色素性疾病中的病理机制和应用原则，以及对VL波长覆盖的最佳光保护。
