PDF(Pubmed)
Abstract：
(1) Background: Atrial cardiomyopathy constitutes an intrinsically prothrombotic atrial substrate that may promote atrial fibrillation and thromboembolic events, especially stroke, independently of the arrhythmia. Atrial reservoir strain is the echocardiography marker with the most robust evidence supporting its prognostic utility. The main aim of this study is to identify atrial cardiomyopathy by investigating the association between left atrial dysfunction in echocardiography and P-wave abnormalities in the surface electrocardiogram. (2) Methods: This is a community-based, multicenter, prospective cohort study. A randomized sample of 100 patients at a high risk of developing atrial fibrillation were evaluated using diverse echocardiography imaging techniques, and a standard electrocardiogram. (3) Results: Significant left atrial dysfunction, expressed by a left atrial reservoir strain < 26%, showed a relationship with the dilation of the left atrium (p < 0.001), the left atrial ejection fraction < 50% (p < 0.001), the presence of advanced interatrial block (p = 0.032), P-wave voltage in lead I < 0.1 mV (p = 0.008), and MVP ECG score (p = 0.036). (4) Conclusions: A significant relationship was observed between left atrial dysfunction and the presence of left atrial enlargement and other electrocardiography markers; all of them are non-invasive biomarkers of atrial cardiomyopathy.
摘要：
（1）背景：心房心肌病构成了一种内在促血栓形成的心房基质，可以促进心房颤动和血栓栓塞事件，尤其是中风,独立于心律失常。心房储层应变是超声心动图标志物，具有最有力的证据支持其预后效用。这项研究的主要目的是通过研究超声心动图中左心房功能障碍与表面心电图中P波异常之间的关联来识别心房心肌病。(2)方法:这是一个以社区为基础的,多中心，前瞻性队列研究。使用不同的超声心动图成像技术评估了100例房颤高风险患者的随机样本。和标准心电图.（3）结果：显著左心房功能障碍，表示为左心房储层应变<26%，显示与左心房扩张的关系（p<0.001），左心房射血分数<50%(p<0.001),晚期房间传导阻滞的存在（p=0.032），导线I中的P波电压<0.1mV（p=0.008），和MVP心电图评分(p=0.036)。(4)结论:左心房功能异常与左心房扩大及其他心电图标志物的存在有显著的相关性,均为心房心肌病的非侵入性生物标志物。
