PDF(Pubmed)
Abstract：
BACKGROUND: Osteoarthritis of the hand joints in systemic sclerosis (SSc) patients might be an independent manifestation leading to limitation of upper extremity function. There is no publication quantitatively assessing the thickness of articular cartilage within the hand joints of SSc patients by MRI. The purpose of our study was to quantify the condition and thickness of hand joints cartilage with three-dimensional quantitative MRI (3D q-MRI).
METHODS: The study was conducted in twenty people: ten patients with SSc and ten healthy individuals. All participants were examined with the 3D q-MRI with 3T scanner. The cartilage thickness of proximal (PIP) and distal interphalangeal (DIP) joints as well as metacarpophalangeal joints was measured.
RESULTS: There was no significant difference in cartilage thickness between both groups. However, the joint cartilage was thinner in fingers with acro-osteolysis. In PIP joint of the fingers with acro-osteolysis, the mean cartilage thickness was 0.5 mm (p = 0.0043) and 0.4 mm (p = 0.0034) in DIP joints.
CONCLUSIONS: Quantitative MRI analysis of the joints of the hands of SSc patients does not indicate changes in thickness of the articular cartilage. A significant reduction in the articular cartilage thickness of the fingers with acro-osteolysis indicates the potential of an ischemic basis of articular cartilage destruction in SSc patients.
METHODS: The study was conducted in twenty people: ten patients with SSc and ten healthy individuals. All participants were examined with the 3D q-MRI with 3T scanner. The cartilage thickness of proximal (PIP) and distal interphalangeal (DIP) joints as well as metacarpophalangeal joints was measured.
RESULTS: There was no significant difference in cartilage thickness between both groups. However, the joint cartilage was thinner in fingers with acro-osteolysis. In PIP joint of the fingers with acro-osteolysis, the mean cartilage thickness was 0.5 mm (p = 0.0043) and 0.4 mm (p = 0.0034) in DIP joints.
CONCLUSIONS: Quantitative MRI analysis of the joints of the hands of SSc patients does not indicate changes in thickness of the articular cartilage. A significant reduction in the articular cartilage thickness of the fingers with acro-osteolysis indicates the potential of an ischemic basis of articular cartilage destruction in SSc patients.
摘要：
背景：系统性硬化症（SSc）患者的手关节骨关节炎可能是导致上肢功能受限的独立表现。尚无通过MRI定量评估SSc患者手关节内关节软骨厚度的出版物。我们研究的目的是通过三维定量MRI（3Dq-MRI）量化手关节软骨的状况和厚度。
方法：该研究在20个人中进行：10名SSc患者和10名健康个体。所有参与者均使用3T扫描仪进行3Dq-MRI检查。测量近端（PIP）和远端指间（DIP）关节以及掌指关节的软骨厚度。
结果：两组之间的软骨厚度没有显着差异。然而,手指关节软骨变薄，关节骨溶解。在手指的PIP关节中，关节骨溶解，DIP关节的平均软骨厚度为0.5mm（p=0.0043）和0.4mm（p=0.0034）。
结论：SSc患者手关节的定量MRI分析未显示关节软骨厚度的变化。关节骨溶解的手指关节软骨厚度的显着减少表明SSc患者关节软骨破坏的缺血性基础的可能性。
方法：该研究在20个人中进行：10名SSc患者和10名健康个体。所有参与者均使用3T扫描仪进行3Dq-MRI检查。测量近端（PIP）和远端指间（DIP）关节以及掌指关节的软骨厚度。
结果：两组之间的软骨厚度没有显着差异。然而,手指关节软骨变薄，关节骨溶解。在手指的PIP关节中，关节骨溶解，DIP关节的平均软骨厚度为0.5mm（p=0.0043）和0.4mm（p=0.0034）。
结论：SSc患者手关节的定量MRI分析未显示关节软骨厚度的变化。关节骨溶解的手指关节软骨厚度的显着减少表明SSc患者关节软骨破坏的缺血性基础的可能性。
