PDF(Pubmed)
Abstract：
There is an increasing recognition of the crucial role of the right ventricle (RV) in determining the functional status and prognosis in multiple conditions. In the past decade, the epigenetic regulation (DNA methylation, histone modification, and non-coding RNAs) of gene expression has been raised as a critical determinant of RV development, RV physiological function, and RV pathological dysfunction. We thus aimed to perform an up-to-date review of the literature, gathering knowledge on the epigenetic modifications associated with RV function/dysfunction. Therefore, we conducted a systematic review of studies assessing the contribution of epigenetic modifications to RV development and/or the progression of RV dysfunction regardless of the causal pathology. English literature published on PubMed, between the inception of the study and 1 January 2023, was evaluated. Two authors independently evaluated whether studies met eligibility criteria before study results were extracted. Amongst the 817 studies screened, 109 studies were included in this review, including 69 that used human samples (e.g., RV myocardium, blood). While 37 proposed an epigenetic-based therapeutic intervention to improve RV function, none involved a clinical trial and 70 are descriptive. Surprisingly, we observed a substantial discrepancy between studies investigating the expression (up or down) and/or the contribution of the same epigenetic modifications on RV function or development. This exhaustive review of the literature summarizes the relevant epigenetic studies focusing on RV in human or preclinical setting.
摘要：
人们越来越认识到右心室（RV）在确定多种疾病的功能状态和预后中的关键作用。在过去的十年里,表观遗传调控(DNA甲基化，组蛋白修饰，和非编码RNA）的基因表达已被认为是RV发育的关键决定因素，RV生理功能，和RV病理性功能障碍。因此，我们的目标是对文献进行最新的回顾，收集与RV功能/功能障碍相关的表观遗传修饰的知识。因此,我们对评估表观遗传修饰对RV发育和/或RV功能障碍进展的贡献的研究进行了系统回顾,而不考虑病因病理学.在PubMed上发表的英语文学，在研究开始至2023年1月1日之间进行了评估。两位作者在提取研究结果之前独立评估了研究是否符合资格标准。在筛选的817项研究中，109项研究纳入本综述，包括使用人类样本的69个(例如，RV心肌，血）。虽然37提出了一种基于表观遗传的治疗干预来改善RV功能，没有一项涉及临床试验,70项是描述性的.令人惊讶的是,我们观察到研究相同表观遗传修饰对RV功能或发育的表达(上调或下调)和/或贡献的研究之间存在显著差异.这篇详尽的文献综述总结了在人类或临床前环境中针对RV的相关表观遗传学研究。
