PDF(Pubmed)
Abstract：
BACKGROUND: Asbestos is considered one of the major global work-related carcinogens. Some studies suggest a potential causal relationship between asbestos exposure and colorectal cancer (CRC). However, the role of asbestos in CRC carcinogenesis is still controversial.
METHODS: 35 claims of occupational CRC among asbestos-exposed workers were reviewed. All claims were rejected by the Italian National Institute for Insurance against Accidents (INAIL) due to the \"lack of scientific evidence in the causality\" between asbestos exposure and CRC; causality was finally assessed in civil trials. All cases were categorized by age, gender, industry type, task, exposure and latency periods, anatomical location, and histopathological characteristics of CRC and concomitant respiratory diseases.
RESULTS: Most workers were males aged 60 years or more and employed in occupational activities with extensive use of asbestos for over 20 years. In 31 out of 35 cases, CRC was diagnosed over 39 years after employment. Right-sided colic adenocarcinoma was diagnosed in nine cases; rectum was involved in eight cases. Respiratory comorbidities were observed in 22 workers.
CONCLUSIONS: Our study provides some interesting points in the assessment of the causal relationship between asbestos exposure and CRC.
METHODS: 35 claims of occupational CRC among asbestos-exposed workers were reviewed. All claims were rejected by the Italian National Institute for Insurance against Accidents (INAIL) due to the \"lack of scientific evidence in the causality\" between asbestos exposure and CRC; causality was finally assessed in civil trials. All cases were categorized by age, gender, industry type, task, exposure and latency periods, anatomical location, and histopathological characteristics of CRC and concomitant respiratory diseases.
RESULTS: Most workers were males aged 60 years or more and employed in occupational activities with extensive use of asbestos for over 20 years. In 31 out of 35 cases, CRC was diagnosed over 39 years after employment. Right-sided colic adenocarcinoma was diagnosed in nine cases; rectum was involved in eight cases. Respiratory comorbidities were observed in 22 workers.
CONCLUSIONS: Our study provides some interesting points in the assessment of the causal relationship between asbestos exposure and CRC.
摘要：
背景：石棉被认为是与工作有关的主要全球致癌物之一。一些研究表明石棉暴露与结直肠癌（CRC）之间存在潜在的因果关系。然而,石棉在CRC癌变中的作用仍存在争议.
方法：回顾了接触石棉的工人中有关职业性CRC的35项索赔。由于石棉暴露与CRC之间“缺乏因果关系的科学证据”，意大利国家事故保险研究所（INAIL）拒绝了所有索赔；因果关系最终在民事审判中进行了评估。所有病例都按年龄分类，性别,行业类型,任务,暴露和延迟周期，解剖位置,CRC的组织病理学特征和伴随的呼吸系统疾病。
结果：大多数工人是60岁或以上的男性，从事职业活动，广泛使用石棉超过20年。在35个病例中，有31个，CRC在就业后超过39年被诊断出来。诊断为右侧结肠腺癌9例；直肠累及8例。在22名工人中观察到呼吸道合并症。
结论：我们的研究为评估石棉暴露与CRC之间的因果关系提供了一些有趣的观点。
方法：回顾了接触石棉的工人中有关职业性CRC的35项索赔。由于石棉暴露与CRC之间“缺乏因果关系的科学证据”，意大利国家事故保险研究所（INAIL）拒绝了所有索赔；因果关系最终在民事审判中进行了评估。所有病例都按年龄分类，性别,行业类型,任务,暴露和延迟周期，解剖位置,CRC的组织病理学特征和伴随的呼吸系统疾病。
结果：大多数工人是60岁或以上的男性，从事职业活动，广泛使用石棉超过20年。在35个病例中，有31个，CRC在就业后超过39年被诊断出来。诊断为右侧结肠腺癌9例；直肠累及8例。在22名工人中观察到呼吸道合并症。
结论：我们的研究为评估石棉暴露与CRC之间的因果关系提供了一些有趣的观点。
