PDF(Pubmed)
Abstract：
The acceptance of nanoparticle technology in the quest for cancer treatment is due to its many potentials and possibilities of filling in the gaps in the limitations of the current treatment modalities. Insights into the possibilities of getting even more from this technology, as well as the synergistic properties of photothermal therapy (PTT) and photodynamic therapy (PDT)-the use of reactive oxygen species (ROS)-can also be exploited in the ablation of prostate cancer tumors. Therefore, the combination of gold and selenium photoactive nanoparticles as platforms for drug delivery via PTT/PDT in prostate cancer therapy, with a specific emphasis on the \'micro-carrier\' based approach, was discussed and explored in this review under relevant subtopics ranging from understanding the complex chemistry and biology of the pharmacologically active Se/Au-containing agents to giving a thorough knowledge of these therapeutic agents\' potential as a targeted and successful treatment strategy for prostate cancer by investigating the complex mechanisms behind their delivery, activation, and synergistic effects. Furthermore, this article presents a comprehensive overview of the current research environment, problems encountered, and future perspectives in the continuous war against prostate cancer.
摘要：
纳米粒子技术在寻求癌症治疗中的接受是由于其填补当前治疗方式局限性空白的许多潜力和可能性。洞察从这项技术中获得更多的可能性，除了光热疗法（PTT）和光动力疗法（PDT）的协同特性-使用活性氧（ROS）-也可以用于前列腺癌肿瘤的消融。因此,金和硒光活性纳米粒子的组合作为通过PTT/PDT在前列腺癌治疗中的药物递送平台，特别强调基于“微载体”的方法，本综述在相关子主题下进行了讨论和探讨，从了解药理活性含硒/金药剂的复杂化学和生物学，到通过研究这些治疗剂作为前列腺癌靶向和成功治疗策略的潜力，全面了解它们的输送背后的复杂机制，激活,和协同效应。此外，本文对当前的研究环境进行了全面的概述，遇到的问题,以及与前列腺癌的持续战争的未来前景。
