Abstract：
Failure to reconstruct the Lactobacillus microbiota is the major reason for the recurrence of vaginal infection. However, most empiric therapies focus on the efficacy of pathogen elimination but do not sufficiently consider the viability of Lactobacillus. Herein, cotton fibers with a lactic acid-like surface (LC) are fabricated by NaIO4 oxidation and L-isoserine grafting. The lactic acid analog chain ends and imine structure of LC can penetrate cell walls to cause protein cleavage in Escherichia coli and Candida albicans and inhibit vaginal pathogens. Meanwhile, the viability of Lactobacillus acidophilus is unaffected by the LC treatment, thus revealing a selective way to suppress pathogens as well as provide a positive route to re-establish protective microbiota in the vaginal tract. Moreover, LC has excellent properties such as good biosafety, antiadhesion, water absorption, and weight retention. The strategy proposed here not only is practical, but also provides insights into the treatment of vaginal infections.
摘要：
未能重建乳杆菌微生物群是阴道感染复发的主要原因。然而,大多数经验性疗法侧重于消除病原体的功效，但没有充分考虑乳酸菌的活力。在这里，通过NaIO4氧化和L-异丝氨酸接枝制备具有乳酸样表面（LC）的棉纤维。LC的乳酸类似物链末端和亚胺结构可以穿透细胞壁以引起大肠杆菌和白色念珠菌中的蛋白质裂解并抑制阴道病原体。同时,嗜酸乳杆菌的活力不受LC处理的影响，从而揭示了一种选择性的方法来抑制病原体，并为在阴道中重新建立保护性微生物群提供了积极的途径。此外，LC具有优异的性能，如良好的生物安全性，防粘连,吸水,和重量保留。这里提出的战略不仅切实可行，而且还提供了对阴道感染治疗的见解。本文受版权保护。保留所有权利。
