Abstract：
Background and Aim: Little is known about whether early menopause in Chinese ethnicity is associated with acute myocardial infarction (AMI). We aimed to determine whether self-reported early menopause (either surgical or natural menopause at an age <50 year) was associated with first AMI in Chinese women. Methods: The study population was from the INTERHEART China Study, part of the INTERHEART global study. INTERHEART global study was a standardized case-control study that was designed to evaluate the risk factors for first AMI among 52 countries. Data for demographic factors, education, income, and cardiovascular risk factors were obtained by structured questionnaires. A standard set of questions that inquired about menstrual history was included in the interview. Results: Of the 1,771 Chinese women, 1,563 (88.3%) reported either natural or surgical menopause. In univariate logistic regression model, women with early menopause had higher risk of AMI (odds ratio [OR]: 1.51; 95% confidence interval [CI]: 1.23-1.87). After controlling for age, birth control measures, type of menopause, and other traditional risk factors (including waist/hip ratio, lifestyle factors, history of hypertension and diabetes, psychosocial factors, and apolipoprotein B [ApoB]/A1 [ApoA1]), the risk for AMI remained (OR: 1.36; 95% CI: 1.03-1.79). The population attributable risk for AMI in women with early menopause at <50 years was 10.1% (95% CI: 4.0-20.0) compared with women who had menopause at ≥50 years. Conclusion: Early menopause is associated with increased risk of AMI in Chinese women, independent of other traditional coronary heart disease risk factors.
摘要：
背景和目的：对于中国人的早期绝经是否与急性心肌梗死（AMI）相关的研究知之甚少。我们旨在确定自我报告的早期绝经（手术或年龄<50岁的自然绝经）是否与中国女性的首次AMI有关。方法：研究人群来自INTERHEART中国研究，INTERHEART全球研究的一部分。INTERHEART全球研究是一项标准化的病例对照研究，旨在评估52个国家中首次AMI的危险因素。人口因素数据，教育,收入,和心血管危险因素通过结构化问卷获得。访谈中包括一组询问月经史的标准问题。结果：在1,771名中国妇女中，1,563（88.3％）报告了自然或手术绝经。在单变量逻辑回归模型中，绝经早期女性患AMI的风险较高(比值比[OR]:1.51;95%置信区间[CI]:1.23~1.87).在控制了年龄之后,节育措施,更年期的类型，和其他传统风险因素(包括腰/臀比，生活方式因素，高血压和糖尿病史，社会心理因素,和载脂蛋白B[ApoB]/A1[ApoA1]），AMI的风险仍然存在（OR：1.36；95％CI：1.03-1.79）。与绝经≥50岁的女性相比，绝经年龄<50岁的女性发生AMI的人群归因风险为10.1％（95％CI：4.0-20.0）。结论:绝经早期与中国女性AMI风险增加有关,独立于其他传统冠心病危险因素。
