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Abstract：
UNASSIGNED: The aim of the study was to evaluate cerebrospinal fluid (CSF) findings in tuberculous meningitis (TBM) and correlate it with severity, radiological features, and outcome of TBM.
UNASSIGNED: In a retrospective study, data from admitted TBM patients were analyzed, and findings of CSF examinations were recorded. The CSF was categorized as typical (protein 50-500 mg/dL, cells 50-500/mm3, and glucose 50% or lower of blood sugar); those above and below these values were categorized as increased or decreased, respectively. The CSF findings were correlated with stage of TBM, and 3-month outcome and radiological features. Paradoxical response was also noted.
UNASSIGNED: There were 111 patients with TBM (definite 34, highly probable 77). On admission, 20 patients were in Stage I, 63 in Stage II, and 28 in Stage III TBM. CSF cells were in typical range in 73, low in 27 and increased in 11 patients. Protein was in typical range in 92 patients decreased in 11 patients and increased in eight patients. Sugar was normal in 41 and reduced in 70 patients. CSF cells, glucose, and protein did not correlate with the severity of meningitis. Fifteen patients had normal initial magnetic resonance imaging (MRI). Tuberculomas were present in 53 patients, hydrocephalus in 43 patients, basal exudates in 43 patients, and infarction in 44 patients. Mixed findings were present in 65 patients. The MRI features did not correlate with CSF. Second CSF was available after a median duration of 26 (13-276) days in 50 patients. The CSF cells were decreased in 20 and increased in 30 patients, protein increased in 30 and sugars decreased in 16 patients. Paradoxical worsening occurred in 27 patients. Fifty-one patients recovered completely, 41 partially, 15 had poor, three patients were lost to follow-up, and one died. CSF parameters did not correlate with 3-month outcome or paradoxical worsening. CSF parameters do not differ significantly between baseline and 1 month CSF, but cells and lymphocytes changed significantly between 1st month and 3rd month CSF.
UNASSIGNED: Typical CSF findings were present in 66% and did not correlate severity of TBM, radiological features paradoxical worsening or 3-month outcome. CSF cell count decreased within 3 months of treatment.
UNASSIGNED: In a retrospective study, data from admitted TBM patients were analyzed, and findings of CSF examinations were recorded. The CSF was categorized as typical (protein 50-500 mg/dL, cells 50-500/mm3, and glucose 50% or lower of blood sugar); those above and below these values were categorized as increased or decreased, respectively. The CSF findings were correlated with stage of TBM, and 3-month outcome and radiological features. Paradoxical response was also noted.
UNASSIGNED: There were 111 patients with TBM (definite 34, highly probable 77). On admission, 20 patients were in Stage I, 63 in Stage II, and 28 in Stage III TBM. CSF cells were in typical range in 73, low in 27 and increased in 11 patients. Protein was in typical range in 92 patients decreased in 11 patients and increased in eight patients. Sugar was normal in 41 and reduced in 70 patients. CSF cells, glucose, and protein did not correlate with the severity of meningitis. Fifteen patients had normal initial magnetic resonance imaging (MRI). Tuberculomas were present in 53 patients, hydrocephalus in 43 patients, basal exudates in 43 patients, and infarction in 44 patients. Mixed findings were present in 65 patients. The MRI features did not correlate with CSF. Second CSF was available after a median duration of 26 (13-276) days in 50 patients. The CSF cells were decreased in 20 and increased in 30 patients, protein increased in 30 and sugars decreased in 16 patients. Paradoxical worsening occurred in 27 patients. Fifty-one patients recovered completely, 41 partially, 15 had poor, three patients were lost to follow-up, and one died. CSF parameters did not correlate with 3-month outcome or paradoxical worsening. CSF parameters do not differ significantly between baseline and 1 month CSF, but cells and lymphocytes changed significantly between 1st month and 3rd month CSF.
UNASSIGNED: Typical CSF findings were present in 66% and did not correlate severity of TBM, radiological features paradoxical worsening or 3-month outcome. CSF cell count decreased within 3 months of treatment.
摘要：
■该研究的目的是评估结核性脑膜炎（TBM）的脑脊液（CSF）发现并将其与严重程度相关联，放射学特征，以及TBM的结果。
■在一项回顾性研究中，对入院的TBM患者的数据进行了分析，并记录脑脊液检查结果。CSF被归类为典型（蛋白质50-500mg/dL，细胞50-500/mm3，葡萄糖为血糖的50％或更低）；高于和低于这些值的被归类为增加或减少，分别。脑脊液检查结果与TBM分期相关，和3个月的结果和放射学特征。还注意到矛盾的反应。
■有111例TBM患者（明确34例，极可能77例）。一入场,20名患者处于I期，第二阶段63人，和28在III级TBM中。CSF细胞在73例患者中处于典型范围，在27例中处于低水平，在11例患者中升高。92例患者的蛋白质在典型范围内，11例患者减少，8例患者增加。41例糖正常，70例糖降低。CSF细胞，葡萄糖，蛋白与脑膜炎的严重程度无关。15例患者的初始磁共振成像（MRI）正常。53例患者出现结核瘤，43例患者出现脑积水，43例患者的基底渗出，和44例患者的梗塞。65例患者存在混合发现。MRI特征与CSF无关。在50例患者中，在中位持续时间为26（13-276）天后可获得第二次CSF。20例患者的CSF细胞减少，30例增加，30例患者的蛋白质增加，16例糖减少。27例患者出现矛盾恶化。51名患者完全康复,41部分，15有可怜的，三名患者失去了随访，一个人死了.CSF参数与3个月预后或矛盾恶化无关。CSF参数在基线和1个月CSF之间没有显着差异，但在第1个月和第3个月之间，CSF的细胞和淋巴细胞发生了显着变化。
■66％的典型脑脊液检查结果与TBM的严重程度无关，放射学特征矛盾恶化或3个月的结果。CSF细胞计数在治疗3个月内下降。
■在一项回顾性研究中，对入院的TBM患者的数据进行了分析，并记录脑脊液检查结果。CSF被归类为典型（蛋白质50-500mg/dL，细胞50-500/mm3，葡萄糖为血糖的50％或更低）；高于和低于这些值的被归类为增加或减少，分别。脑脊液检查结果与TBM分期相关，和3个月的结果和放射学特征。还注意到矛盾的反应。
■有111例TBM患者（明确34例，极可能77例）。一入场,20名患者处于I期，第二阶段63人，和28在III级TBM中。CSF细胞在73例患者中处于典型范围，在27例中处于低水平，在11例患者中升高。92例患者的蛋白质在典型范围内，11例患者减少，8例患者增加。41例糖正常，70例糖降低。CSF细胞，葡萄糖，蛋白与脑膜炎的严重程度无关。15例患者的初始磁共振成像（MRI）正常。53例患者出现结核瘤，43例患者出现脑积水，43例患者的基底渗出，和44例患者的梗塞。65例患者存在混合发现。MRI特征与CSF无关。在50例患者中，在中位持续时间为26（13-276）天后可获得第二次CSF。20例患者的CSF细胞减少，30例增加，30例患者的蛋白质增加，16例糖减少。27例患者出现矛盾恶化。51名患者完全康复,41部分，15有可怜的，三名患者失去了随访，一个人死了.CSF参数与3个月预后或矛盾恶化无关。CSF参数在基线和1个月CSF之间没有显着差异，但在第1个月和第3个月之间，CSF的细胞和淋巴细胞发生了显着变化。
■66％的典型脑脊液检查结果与TBM的严重程度无关，放射学特征矛盾恶化或3个月的结果。CSF细胞计数在治疗3个月内下降。
