An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients - A study of T cells and natural killer cells.

外周血中调节性 T 细胞的增加与恶性黑色素瘤患者的不良预后相关 - T 细胞和自然杀伤细胞的研究。

• 发表时间: 2024
• 来源期刊: Curr Res Immunol
• DOI: 10.1016/j.crimmu.2023.100074
• PMID: 38059204
• 文章类型: Journal Article
• 作者列表: Heldager Pedersen N,Bjerregaard Jeppesen H,Persson G,Bojesen S,Hviid TVF

关键词: Immune marker; Malignant melanoma; NK cell; Survival; T cell

Abstract

Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of CD4+ T cells and increased levels of CD8+ T cells in peripheral blood from malignant melanoma patients compared with controls. Percentages of peripheral CD56dimCD16+ NK cells were reduced and CD56brightCD16-KIR3+ NK cells were increased in malignant melanoma patients. Late stage malignant melanoma was correlated with low levels of CD4+ T cells and high levels of CD56brightCD16-KIR3+ NK cells. Finally, high levels of Tregs in peripheral blood were correlated with poor overall survival and disease-free survival. The results indicate that changes in specific immune cell subsets in peripheral blood samples from patients at the time of diagnosis may be potential biomarkers for prognosis and survival. Further studies will enable clarification of independent roles in tumour pathogenesis.

摘要

恶性黑色素瘤是一种高度免疫原性的肿瘤，免疫谱显著影响癌症的发展和对免疫疗法的反应。外周免疫谱可以识别高风险患者。当前的研究显示，与对照组相比，恶性黑色素瘤患者外周血中CD4T细胞水平降低，CD8T细胞水平升高。恶性黑色素瘤患者外周血CD56dimCD16NK细胞的百分比减少，CD56brightCD16-KIR3NK细胞的百分比增加。晚期恶性黑色素瘤与低水平的CD4T细胞和高水平的CD56brightCD16-KIR3NK细胞相关。最后,外周血中高水平的Tregs与不良的总生存率和无病生存率相关.结果表明，诊断时患者外周血样本中特定免疫细胞亚群的变化可能是预后和生存的潜在生物标志物。进一步的研究将能够阐明在肿瘤发病机理中的独立作用。