Abstract：
<b><br>Introduction:</b> Dupuytren\'s disease is a common fibrotic disorder of the palmar aponeurosis characterized by the formation of nodules and cords, as well as development of progressive flexion deformities in the digits, leading to functional impairment. Surgical excision of the affected aponeurosis remains the most common treatment. Quite a few new information appeared about epidemiology, pathogenesis and particularly treatment of the disorder.</br> <b><br>Aim:</b> The aim of this study is an updated review of scientific data in this topic.</br> <b><br>Results:</b> Results of epidemiologic studies showed that Dupuytren\'s disease is not so uncommon in Asian and African population as it was earlier believed. An important role of genetic factors on development of the disease in a proportion of patients was demonstrated, however, it did not translate neither to the treatment nor to the prognosis. The most changes concerned the management of Dupuytren\'s disease. A positive effect of steroids injections into the nodules and cords for inhibition of the disease in early stages was shown. In the advanced stages, a standard technique of partial fasciectomy was partly replaced by mini-invasive methods such as needle fasciotomy and collagenase Clostirdium hystolyticum injections. Unexpected withdrawal of collagenase from the market in 2020 resulted in considerable limitation of the availability of this treatment.</br> <b><br>Conclusion:</b> It seems that updated knowledge on Dupuytren\'s disease may be interested and useful for surgeons involved in management of the disorder.</br>.
摘要：
<b><br>简介:</b>Dupuytren病是一种常见的掌腱膜纤维化疾病，其特征是结节和索的形成，以及手指进行性屈曲畸形的发展，导致功能损害。受影响的肌腱膜的手术切除仍然是最常见的治疗方法。相当多关于流行病学的新信息出现了，发病机制，特别是治疗疾病。</br><b>br>目的：</b>本研究的目的是对本主题中的科学数据进行最新回顾。</br><b><br>结果：</b>流行病学研究结果表明，Dupuytren的疾病在亚洲和非洲人群中并不罕见，因为它被认为是早期的。在一定比例的患者中，遗传因素对疾病的发展具有重要作用，然而,它既不能转化为治疗，也不能转化为预后。大多数变化涉及Dupuytren病的管理。显示了向结节和索中注射类固醇对早期抑制疾病的积极作用。在高级阶段，部分筋膜切除术的标准技术部分被微创方法所取代，例如针状筋膜切开术和胶原酶注射。胶原酶在2020年意外退出市场，导致这种治疗的可用性受到相当大的限制。</br><b><br>结论：</b>看来，有关Dupuytren病的最新知识可能对参与该疾病管理的外科医生感兴趣和有用。</br>.
