Abstract：
Neuropathy is a terrible disorder that has a wide range of etiologies. Drug-induced neuropathy, which happens whenever a chemical agent damages the peripheral nerve system, has been linked here to the iatrogenic creation of some drugs. It is potentially permanent and causes sensory impairments and paresthesia that typically affects the hands, feet, and stockings; motor participation is uncommon. It might appear suddenly or over time, and the long-term outlook varies. The wide range of chronic pain conditions experienced by people has been one of the main obstacles to developing new, more effective medications for the treatment of neuropathic pain. Animal models can be used to examine various neuropathic pain etiologies and symptoms. Several models investigate the peripheral processes of neuropathic pain, whereas some even investigate the central mechanisms, such as drug induce models like vincristine, cisplatin, bortezomib, or thalidomide, etc., and surgical models like sciatic nerve chronic constriction injury (CCI), sciatic nerve ligation through spinal nerve ligation (SNL), sciatic nerve damage caused by a laser, SNI (spared nerve injury), etc. The more popular animal models relying on peripheral nerve ligatures are explained. In contrast to chronic sciatic nerve contraction, which results in behavioral symptoms of less reliable stressful neuropathies, (SNI) spared nerve injury generates behavioral irregularities that are more feasible over a longer period. This review summarizes the latest methods models as well as clinical ideas concerning this mechanism. Every strongest current information on neuropathy is discussed, along with several popular laboratory models for causing neuropathy.
摘要：
神经病是一种可怕的疾病，病因广泛。药物性神经病,每当化学试剂损害外周神经系统时，都会发生这种情况，在这里与一些药物的医源性创造有关。它可能是永久性的，会导致感觉障碍和感觉异常，通常会影响手，脚,和长袜；运动参与并不常见。它可能会突然出现或随着时间的推移，长期前景各异。人们所经历的各种慢性疼痛状况一直是开发新的主要障碍之一，更有效的治疗神经性疼痛的药物。动物模型可用于检查各种神经性疼痛病因和症状。几个模型研究了神经性疼痛的外周过程，而有些人甚至调查了中心机制，如药物诱导的模型，如长春新碱，顺铂,硼替佐米,或者沙利度胺,等。,和坐骨神经慢性压迫性损伤（CCI）等手术模型，通过脊神经结扎（SNL）进行坐骨神经结扎，激光引起的坐骨神经损伤,SNI（幸免神经损伤），等。解释了依靠周围神经结扎的更流行的动物模型。与慢性坐骨神经收缩相反，导致不那么可靠的应激性神经病的行为症状，（SNI）幸免的神经损伤会产生行为不规则性，这在更长的时间内更可行。本文总结了有关该机制的最新方法模型以及临床观点。讨论了所有关于神经病变的最新信息，以及几种流行的导致神经病变的实验室模型。
