关键词: (201)Tl]TlCl 30 MeV cyclotron Ischemia Pharmacopeia SPECT/CT

Mesh : Cyclotrons Pharmaceutical Preparations Thallium / analysis

来  源:   DOI:10.1016/j.apradiso.2023.111128

Abstract:
Multiple patient doses of [201Tl]TlCl has been produced using electrodeposited enriched 203Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 μA beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [201Tl]TlCl. The produced [201Tl]TlCl was used in coronary artery disease (CAD) patients.
摘要:
使用电沉积富集的203Tl在30MeV回旋加速器(Cyclone-30)中产生了多个患者剂量的[201Tl]TlCl,在50μA束流下具有28MeV质子能量,持续8小时。离子交换柱色谱(IECC)和液-液萃取已用于半自动放射化学分离和纯化产生的[201Tl]TlCl。产生的[201Tl]TlCl用于冠状动脉疾病(CAD)患者。
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