Abstract：
OBJECTIVE: To assess the therapeutic efficacy of acupuncture in combination with Chinese herbs for treatment of horses affected with anhidrosis.
METHODS: 44 horses affected with anhidrosis for up to 3 years\' duration were enrolled. Inclusion required both compatible clinical signs and results of a quantitative intradermal terbutaline sweat test.
METHODS: Study horses were randomly allocated into 2 groups. Group 1 (n = 19) was treated with daily Chinese herbs and 4 weekly acupuncture sessions. Group 2 (n = 25) was given daily hay powder as a placebo and 4 weekly sham acupuncture sessions. Horses were tested by quantitative intradermal terbutaline sweat test within 2 days after treatment completion and again 4 weeks following treatment.
RESULTS: Terbutaline-induced sweat responses (mg) were not different between groups within 2 days and 4 weeks after treatment. Two days after treatment, ratios of sweat responses (compared to baseline) were higher (P < .05) in the treatment group compared to the placebo group at terbutaline concentrations of 1.0, 100, and 1,000 µg/mL. The number of horses responding to treatment was higher in the treatment group (5/19 [26%]), compared to horses in the placebo group (1/25 [4%]) for 1 of 5 terbutaline concentrations 2 days (10 µg/mL) or 4 weeks (0.1 µg/mL) after treatment.
CONCLUSIONS: Ratios of sweat responses were higher in treatment horses 2 days after treatment, compared to baseline, but not 4 weeks later. The efficacy of a traditional Chinese veterinary medicine protocol for anhidrosis treatment with acupuncture and Chinese herbs was low but higher in treated horses compared with placebo.
METHODS: 44 horses affected with anhidrosis for up to 3 years\' duration were enrolled. Inclusion required both compatible clinical signs and results of a quantitative intradermal terbutaline sweat test.
METHODS: Study horses were randomly allocated into 2 groups. Group 1 (n = 19) was treated with daily Chinese herbs and 4 weekly acupuncture sessions. Group 2 (n = 25) was given daily hay powder as a placebo and 4 weekly sham acupuncture sessions. Horses were tested by quantitative intradermal terbutaline sweat test within 2 days after treatment completion and again 4 weeks following treatment.
RESULTS: Terbutaline-induced sweat responses (mg) were not different between groups within 2 days and 4 weeks after treatment. Two days after treatment, ratios of sweat responses (compared to baseline) were higher (P < .05) in the treatment group compared to the placebo group at terbutaline concentrations of 1.0, 100, and 1,000 µg/mL. The number of horses responding to treatment was higher in the treatment group (5/19 [26%]), compared to horses in the placebo group (1/25 [4%]) for 1 of 5 terbutaline concentrations 2 days (10 µg/mL) or 4 weeks (0.1 µg/mL) after treatment.
CONCLUSIONS: Ratios of sweat responses were higher in treatment horses 2 days after treatment, compared to baseline, but not 4 weeks later. The efficacy of a traditional Chinese veterinary medicine protocol for anhidrosis treatment with acupuncture and Chinese herbs was low but higher in treated horses compared with placebo.
摘要：
目的：评价针刺配合中药治疗马无汗症的疗效。
方法：纳入44匹患有无汗症长达3年的马。纳入需要相容的临床体征和定量的特布他林皮内汗液测试的结果。
方法：研究马匹随机分为两组。第1组（n=19）每天接受中药治疗，每周接受4次针灸治疗。第2组（n=25）每天给予干草粉作为安慰剂，每周给予4次假针灸。在治疗完成后2天内和在治疗后4周再次通过定量皮内特布他林汗液测试来测试马。
结果：特布他林诱导的汗液反应（mg）在治疗后2天和4周内在组间没有差异。治疗后两天,在特布他林浓度为1.0,100和1,000µg/mL时,治疗组的汗液反应比率(与基线相比)高于安慰剂组(P<.05).对治疗有反应的马数在治疗组中较高(5/19[26%]),与安慰剂组的马(1/25[4%])相比，治疗后2天(10µg/mL)或4周(0.1µg/mL)的5特布他林浓度中的1。
结论：治疗后2天，治疗马的汗液反应比率更高，与基线相比，但不是4周后。与安慰剂相比，针灸和中草药治疗无汗症的中医兽医方案的疗效较低，但在治疗马匹中的疗效较高。
方法：纳入44匹患有无汗症长达3年的马。纳入需要相容的临床体征和定量的特布他林皮内汗液测试的结果。
方法：研究马匹随机分为两组。第1组（n=19）每天接受中药治疗，每周接受4次针灸治疗。第2组（n=25）每天给予干草粉作为安慰剂，每周给予4次假针灸。在治疗完成后2天内和在治疗后4周再次通过定量皮内特布他林汗液测试来测试马。
结果：特布他林诱导的汗液反应（mg）在治疗后2天和4周内在组间没有差异。治疗后两天,在特布他林浓度为1.0,100和1,000µg/mL时,治疗组的汗液反应比率(与基线相比)高于安慰剂组(P<.05).对治疗有反应的马数在治疗组中较高(5/19[26%]),与安慰剂组的马(1/25[4%])相比，治疗后2天(10µg/mL)或4周(0.1µg/mL)的5特布他林浓度中的1。
结论：治疗后2天，治疗马的汗液反应比率更高，与基线相比，但不是4周后。与安慰剂相比，针灸和中草药治疗无汗症的中医兽医方案的疗效较低，但在治疗马匹中的疗效较高。
