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Abstract：
Hyperviscosity syndrome (HVS) is a complication of monoclonal plasma cell tumors. The frequency of HVS depends on the type of monoclonal protein. Immunoglobulin M (IgM) is more closely associated with HVS than IgG, and among IgG subclass monoclonal proteins, IgG3 is most frequently associated with HVS. We herein report a 44-year-old woman with multiple myeloma (MM), HVS, and cryoglobulinemia. Her monoclonal protein and cryoglobulin were IgG1-lambda (λ). She developed HVS at a lower monoclonal protein level because of the properties of the IgG1-derived monoclonal protein and cryoglobulin. Our case highlights the fact that identifying the IgG subclass is useful in predicting the risk of complicating HVS.
摘要：
高粘血症（HVS）是单克隆浆细胞肿瘤的并发症。HVS的频率取决于单克隆蛋白的类型。免疫球蛋白M（IgM）与HVS的关系比IgG更为密切，在IgG亚类单克隆蛋白中，IgG3最常与HVS相关。我们在此报告一名44岁的多发性骨髓瘤（MM）女性，HVS,和冷球蛋白血症.她的单克隆蛋白和冷球蛋白是IgG1-lambda(λ)。由于IgG1衍生的单克隆蛋白和冷球蛋白的特性，她在较低的单克隆蛋白水平上开发了HVS。我们的案例强调了一个事实，即识别IgG亚类有助于预测HVS复杂化的风险。
