PDF(Pubmed)
Abstract：
Parkinson\'s disease (PD) is characterized by extrapyramidal motor disturbances and nonmotor cognitive impairments which impact activities of daily living. Although the etiology of PD is still obscure, autopsy reports suggest that oxidative stress (OS) is one of the important factors in the pathophysiology of PD. In the current study, we have investigated the impact of OS in PD by measuring the antioxidant glutathione (GSH) levels from the substantia nigra (SN), left hippocampus (LH) and neurotransmitter γ-amino butyric acid (GABA) levels from SN region. Concomitant quantitative susceptibility mapping (QSM) from SN and LH was also acquired from thirty-eight PD patients and 30 age-matched healthy controls (HC). Glutathione levels in the SN region decreased significantly and susceptibility increased significantly in PD compared to HC. Nonsignificant depletion of GABA was observed in the SN region. GSH levels in the LH region were depleted significantly, but LH susceptibility did not alter in the PD cohort compared to HC. Neuropsychological and physical assessment demonstrated significant impairment of cognitive functioning in PD patients compared to HC. GSH depletion was negatively correlated to motor function performance. Multivariate receiver operating characteristic (ROC) curve analysis on the combined effect of GSH, GABA, and susceptibility in the SN region yielded an improved diagnostic accuracy of 86.1% compared to individual diagnostic accuracy based on GSH (65.8%), GABA (57.5%), and susceptibility (69.6%). This is the first comprehensive report in PD demonstrating significant GSH depletion as well as concomitant iron enhancement in the SN region.
摘要：
帕金森病（PD）的特征是锥体外系运动障碍和非运动性认知障碍，影响日常生活活动。虽然PD的病因尚不清楚,尸检报告表明，氧化应激（OS）是PD病理生理的重要因素之一。在目前的研究中,我们通过测量黑质（SN）的抗氧化剂谷胱甘肽（GSH）水平来研究OS在PD中的影响，左侧海马（LH）和神经递质γ-氨基丁酸（GABA）水平来自SN区。还从38名PD患者和30名年龄匹配的健康对照（HC）获得了来自SN和LH的伴随定量敏感性图（QSM）。与HC相比，PD中SN区域的谷胱甘肽水平显着降低，而易感性显着增加。在SN区域中观察到GABA的非显著消耗。LH地区的GSH水平显着减少，但与HC相比,PD队列中LH易感性没有改变.神经心理和身体评估表明，与HC相比，PD患者的认知功能明显受损。GSH耗竭与运动功能表现呈负相关。多变量受试者工作特征(ROC)曲线分析对GSH,GABA,与基于GSH的个体诊断准确性（65.8％）相比，SN区域的易感性提高了86.1％的诊断准确性，GABA（57.5%），和易感性（69.6%）。这是PD中的第一份全面报告，表明SN区域的GSH显着消耗以及伴随的铁增强。
