Abstract：
The incidence of kidney disease from acute and chronic conditions continues to escalate worldwide. Interventions to replace renal function after organ failure remain limited to dialysis or transplantation, as human kidneys exhibit a limited capacity to repair damaged cells or regenerate new ones. In contrast, animals ranging from flies to fishes and even some mammals like the spiny mouse exhibit innate abilities to regenerate their kidney cells following injury. Now, a recent study has illuminated how the Mexican salamander, Ambystoma mexicanum, most commonly known as the axolotl, possesses a kidney with remarkable similarity to humans, which can robustly regenerate following acute chemical damage. These discoveries position the axolotl as a new model that can be used to advance our understanding about the fundamental mechanisms of kidney regeneration.
摘要：
来自急性和慢性病症的肾脏疾病的发病率在世界范围内持续增加。器官衰竭后替代肾功能的干预措施仍然限于透析或移植，因为人类肾脏修复受损细胞或再生新细胞的能力有限。相比之下,从苍蝇到鱼类的动物，甚至一些像多刺小鼠这样的哺乳动物都表现出先天的能力，在受伤后再生它们的肾细胞。现在,最近的一项研究阐明了墨西哥sal是如何，Ambystomamexicanum,最常见的是axolotl，拥有一个与人类非常相似的肾脏，在急性化学损伤后可以强劲地再生。这些发现将axolotl定位为一种新模型，可用于增进我们对肾脏再生基本机制的理解。
