PDF(Pubmed)
Abstract：
UNASSIGNED: Scurvy is an uncommon medical condition that affects children and is caused by an inadequate intake of vitamin C. This study presents the characteristics of patients with scurvy to raise awareness of the diagnostic process in developing countries where laboratory testing for vitamin C levels is often not available.
UNASSIGNED: A retrospective study was performed from period of 2018 to 2023. Data extraction includes patient age, sex, body mass index, constitutional symptoms, musculoskeletal, mucosal, cutaneous symptoms, other accompanying disorders, anemia, erythrocyte sedimentation rate, C-reactive protein, radiographic examination, vitamin C dose, and duration of treatment. Descriptive statistical analysis was performed in this study.
UNASSIGNED: Eighteen cases (17 males, 1 female) of scurvy were referred to our institution. Thirteen of 18 patients were misdiagnosed before referral. The median age at presentation was 4.5 (range, 2-11) years. The average body mass index was 13.93 ± 0.63 kg/m2. Half of patients had healthy weight. All patients presented with lower limb pain and 17 of 18 with refusal to walk. The median onset of diagnosis was 11 (range 4-48) weeks. White line of Frankel was described in all patients. Seven had anemia and 6 of 18 had increase in erythrocyte sedimentation rate and/or C-reactive protein levels. Only one patient had ascorbic acid levels evaluation before treatment since it was not readily available in our country. Treatment length varied from 2 weeks to 6 months.
UNASSIGNED: The diagnosis of scurvy is frequently delayed due to its extreme rarity in modern society and its ability to mimic numerous other conditions. In children presenting with limb pain and/or reluctance to walk and pathognomonic radiological findings, physicians must prioritize scurvy as a differential diagnosis. In scurvy, vitamin C supplementation is curative.
UNASSIGNED: A retrospective study was performed from period of 2018 to 2023. Data extraction includes patient age, sex, body mass index, constitutional symptoms, musculoskeletal, mucosal, cutaneous symptoms, other accompanying disorders, anemia, erythrocyte sedimentation rate, C-reactive protein, radiographic examination, vitamin C dose, and duration of treatment. Descriptive statistical analysis was performed in this study.
UNASSIGNED: Eighteen cases (17 males, 1 female) of scurvy were referred to our institution. Thirteen of 18 patients were misdiagnosed before referral. The median age at presentation was 4.5 (range, 2-11) years. The average body mass index was 13.93 ± 0.63 kg/m2. Half of patients had healthy weight. All patients presented with lower limb pain and 17 of 18 with refusal to walk. The median onset of diagnosis was 11 (range 4-48) weeks. White line of Frankel was described in all patients. Seven had anemia and 6 of 18 had increase in erythrocyte sedimentation rate and/or C-reactive protein levels. Only one patient had ascorbic acid levels evaluation before treatment since it was not readily available in our country. Treatment length varied from 2 weeks to 6 months.
UNASSIGNED: The diagnosis of scurvy is frequently delayed due to its extreme rarity in modern society and its ability to mimic numerous other conditions. In children presenting with limb pain and/or reluctance to walk and pathognomonic radiological findings, physicians must prioritize scurvy as a differential diagnosis. In scurvy, vitamin C supplementation is curative.
摘要：
镰刀症是一种罕见的疾病，影响儿童，是由维生素C摄入不足引起的。这项研究介绍了镰刀症患者的特征，以提高发展中国家对诊断过程的认识，这些国家通常没有维生素C水平的实验室检测。
■2018年至2023年进行了一项回顾性研究。数据提取包括患者年龄，性别,身体质量指数,宪法症状，肌肉骨骼，粘膜，皮肤症状,其他伴随的疾病，贫血,红细胞沉降率,C反应蛋白,射线照相检查,维生素C剂量，和治疗的持续时间。本研究进行描述性统计分析。
■18例（男性17例，1名女性）的镰刀病被提交给我们的机构。18例患者中有13例在转诊前被误诊。演示时的平均年龄为4.5岁（范围，2-11）年。平均体重指数为13.93±0.63kg/m2。一半的患者体重健康。所有患者均表现为下肢疼痛，18例中有17例拒绝行走。诊断的中位数为11（范围4-48）周。所有患者均描述了Frankel白线。7人贫血，18人中有6人红细胞沉降率和/或C反应蛋白水平增加。只有一名患者在治疗前进行了抗坏血酸水平评估，因为在我国尚不容易获得。治疗时间从2周到6个月不等。
■由于其在现代社会中极为罕见，并且能够模仿许多其他条件，因此经常延迟诊断。在出现肢体疼痛和/或不愿行走以及病理放射学发现的儿童中，医生必须优先考虑作为鉴别诊断。在镰刀症中，补充维生素C是有疗效的。
■2018年至2023年进行了一项回顾性研究。数据提取包括患者年龄，性别,身体质量指数,宪法症状，肌肉骨骼，粘膜，皮肤症状,其他伴随的疾病，贫血,红细胞沉降率,C反应蛋白,射线照相检查,维生素C剂量，和治疗的持续时间。本研究进行描述性统计分析。
■18例（男性17例，1名女性）的镰刀病被提交给我们的机构。18例患者中有13例在转诊前被误诊。演示时的平均年龄为4.5岁（范围，2-11）年。平均体重指数为13.93±0.63kg/m2。一半的患者体重健康。所有患者均表现为下肢疼痛，18例中有17例拒绝行走。诊断的中位数为11（范围4-48）周。所有患者均描述了Frankel白线。7人贫血，18人中有6人红细胞沉降率和/或C反应蛋白水平增加。只有一名患者在治疗前进行了抗坏血酸水平评估，因为在我国尚不容易获得。治疗时间从2周到6个月不等。
■由于其在现代社会中极为罕见，并且能够模仿许多其他条件，因此经常延迟诊断。在出现肢体疼痛和/或不愿行走以及病理放射学发现的儿童中，医生必须优先考虑作为鉴别诊断。在镰刀症中，补充维生素C是有疗效的。
