关键词: disease management hirsutism polycystic ovary syndrome symptom assessment therapeutics

Mesh : Female Humans Androgens Canada Hirsutism / diagnosis drug therapy Receptors, Androgen

来  源:   DOI:10.1016/j.jogc.2023.102272

Abstract:
This guideline reviews the etiology, diagnosis, evaluation, and treatment of hirsutism.
Women with hirsutism.
Three approaches to management include: 1) mechanical hair removal; 2) suppression of androgen production; and 3) androgen receptor blockade.
The main limitations of the management options include the adverse effects, costs, and duration of treatment.
Implementation of the recommendations in this guideline may improve the management of hirsutism in women with this condition. Adverse effects and a potential long duration of treatment are the main drawbacks to initiating treatment, as is the possibility of significant financial costs for certain treatments.
A comprehensive literature review was updated to April 2022, following the same methods as for the prior Society of Obstetricians and Gynaecologists of Canada (SOGC) Hirsutism guidelines. Results were restricted to systematic reviews, randomized controlled trials, controlled clinical trials, and observational studies. There were no date limits, but results were limited to English- or French-language materials.
The authors rated the quality of evidence and strength of recommendations using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, along with the option of designating a recommendation as a \"good practice point.\" See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and conditional [weak] recommendations).
Primary care providers, family medicine physicians, obstetricians and gynaecologists, reproductive endocrinologists and others who manage the care of patients with hirsutism.
Management of hirsutism involves a 3-pronged approach of mechanical hair removal, suppression of androgen production, and androgen receptor blockade.
RECOMMENDATIONS.
摘要:
目的:本指南回顾了病因,诊断,评估,和多毛症的治疗。
方法:多毛症妇女。
方法:三种管理方法包括:1)机械脱毛;2)抑制雄激素产生;和3)雄激素受体阻断。
结果:管理选项的主要限制包括不利影响,成本,和治疗的持续时间。
结果:实施本指南中的建议可能会改善患有这种疾病的女性多毛症的管理。副作用和潜在的长期治疗是开始治疗的主要缺点,某些治疗可能会产生巨大的财务成本。
方法:按照与先前的加拿大妇产科医师协会(SOGC)多毛症指南相同的方法,将综合文献综述更新至2022年4月。结果仅限于系统评价,随机对照试验,对照临床试验,和观察性研究。没有日期限制,但结果仅限于英语或法语材料。
方法:作者使用改进的“建议分级评估”对证据质量和建议强度进行了评估,开发和评估(等级)方法,以及将建议指定为“良好实践点”的选项。\"见在线附录A(表A1的定义和A2的强和有条件的[弱]建议的解释)。
初级保健提供者,家庭医生,妇产科医生,生殖内分泌学家和其他管理多毛症患者护理的人。
结论:多毛症的管理涉及机械脱毛的三管齐下的方法,抑制雄激素产生,和雄激素受体阻断。
结论:建议。
公众号