Abstract：
Systemic antimicrobial treatments are commonly prescribed to dogs with acute diarrhoea, while nutraceuticals (prebiotics, probiotics, and synbiotics) are frequently administered as an alternative treatment. The aim of this systematic review and meta-analysis was to assess the effectiveness of antimicrobials and nutraceutical preparations for treatment of canine acute diarrhoea (CAD). The results of this study will be used to create evidence-based treatment guidelines. PICOs (population, intervention, comparator, and outcome) were generated by a multidisciplinary expert panel taking into account opinions from stakeholders (general practitioners and dog owners). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to evaluate the certainty of the evidence. The systematic search yielded six randomised controlled trials (RCT) for antimicrobial treatment and six RCTs for nutraceutical treatment meeting the eligibility criteria. Categories of disease severity (mild, moderate, and severe) were created based on the presence of systemic signs and response to fluid therapy. Outcomes included duration of diarrhoea, duration of hospitalization, progression of disease, mortality, and adverse effects. High certainty evidence showed that antimicrobial treatment did not have a clinically relevant effect on any outcome in dogs with mild or moderate disease. Certainty of evidence was low for dogs with severe disease. Nutraceutical products did not show a clinically significant effect in shortening the duration of diarrhoea (based on very low to moderate certainty evidence). No adverse effects were reported in any of the studies.
摘要：
全身抗菌治疗通常适用于患有急性腹泻的狗，而营养保健品(益生元，益生菌，和合生元）经常作为替代治疗。本系统评价和荟萃分析的目的是评估抗生素和营养制剂治疗犬急性腹泻（CAD）的有效性。这项研究的结果将用于创建基于证据的治疗指南。PICOs(人口，干预，比较器,和结果）由一个多学科专家小组产生，并考虑了利益相关者（全科医生和狗主人）的意见。建议评估的分级，使用开发和评估（GRADE）方法来评估证据的确定性。系统搜索产生了符合资格标准的六项用于抗微生物治疗的随机对照试验（RCT）和六项用于营养治疗的RCT。疾病严重程度的类别（轻度，中度,和严重）是基于全身体征的存在和对液体治疗的反应而产生的。结果包括腹泻的持续时间，住院时间，疾病进展，死亡率,和不利影响。高确定性证据表明，抗微生物治疗对患有轻度或中度疾病的狗的任何结果没有临床相关影响。对于患有严重疾病的狗，证据的确定性很低。营养保健品产品在缩短腹泻持续时间方面没有临床上显著的效果(基于非常低至中等的确定性证据)。在任何研究中均未报告不良反应。
