PDF(Pubmed)
Abstract：
UNASSIGNED: A systematic review and meta-analysis.
UNASSIGNED: Treatment of traumatic optic neuropathy (TON) has been a subject of debate for many decades due to the scarcity of evidence-based treatment protocols. This review compares surgical decompression (SD) and steroid therapy (ST) as treatment approaches in TON patients.
UNASSIGNED: A PRISMA-guided systematic review using PubMed, Embase, Ovid and Scopus databases was performed till the last search date of July 31st 2021. The outcome of interest was an improvement in visual acuity. A meta-analysis of the odds ratio was performed using a random-effect model and sub-group analysis based upon criteria for assessment of improvement in visual acuity.
UNASSIGNED: Sixteen studies (including 1046 patients) were included in the review. The review could identify 590 patients treated with SD and 456 treated with ST. In addition, there was a second cohort of patients presenting with NLP (no light perception). A meta-analysis with a sub-group analysis revealed that there was statistically no significant difference between the two treatment approaches in terms of improvement in VA.
UNASSIGNED: There is no difference in treatment results of SD or ST for TON. Several treatment protocols and different criteria for assessing visual acuity led to difficulty in generating evidence for selecting the correct treatment approach.
UNASSIGNED: Treatment of traumatic optic neuropathy (TON) has been a subject of debate for many decades due to the scarcity of evidence-based treatment protocols. This review compares surgical decompression (SD) and steroid therapy (ST) as treatment approaches in TON patients.
UNASSIGNED: A PRISMA-guided systematic review using PubMed, Embase, Ovid and Scopus databases was performed till the last search date of July 31st 2021. The outcome of interest was an improvement in visual acuity. A meta-analysis of the odds ratio was performed using a random-effect model and sub-group analysis based upon criteria for assessment of improvement in visual acuity.
UNASSIGNED: Sixteen studies (including 1046 patients) were included in the review. The review could identify 590 patients treated with SD and 456 treated with ST. In addition, there was a second cohort of patients presenting with NLP (no light perception). A meta-analysis with a sub-group analysis revealed that there was statistically no significant difference between the two treatment approaches in terms of improvement in VA.
UNASSIGNED: There is no difference in treatment results of SD or ST for TON. Several treatment protocols and different criteria for assessing visual acuity led to difficulty in generating evidence for selecting the correct treatment approach.
摘要：
■系统评价和荟萃分析。
■由于缺乏循证治疗方案，几十年来，创伤性视神经病变（TON）的治疗一直是争论的话题。这篇综述比较了手术减压（SD）和类固醇治疗（ST）作为TON患者的治疗方法。
■使用PubMed进行PRISMA指导的系统审查，Embase,Ovid和Scopus数据库一直执行到2021年7月31日的最后搜索日期。感兴趣的结果是视力的改善。根据评估视力改善的标准，使用随机效应模型和亚组分析对比值比进行荟萃分析。
■16项研究（包括1046例患者）纳入本综述。该审查可以确定590例接受SD治疗的患者和456例接受ST治疗的患者。此外,第二组患者出现NLP(无光感).具有亚组分析的荟萃分析显示，就VA的改善而言，两种治疗方法之间没有统计学上的显着差异。
■对于TON，SD或ST的治疗结果没有差异。几种治疗方案和评估视力的不同标准导致难以产生选择正确治疗方法的证据。
■由于缺乏循证治疗方案，几十年来，创伤性视神经病变（TON）的治疗一直是争论的话题。这篇综述比较了手术减压（SD）和类固醇治疗（ST）作为TON患者的治疗方法。
■使用PubMed进行PRISMA指导的系统审查，Embase,Ovid和Scopus数据库一直执行到2021年7月31日的最后搜索日期。感兴趣的结果是视力的改善。根据评估视力改善的标准，使用随机效应模型和亚组分析对比值比进行荟萃分析。
■16项研究（包括1046例患者）纳入本综述。该审查可以确定590例接受SD治疗的患者和456例接受ST治疗的患者。此外,第二组患者出现NLP(无光感).具有亚组分析的荟萃分析显示，就VA的改善而言，两种治疗方法之间没有统计学上的显着差异。
■对于TON，SD或ST的治疗结果没有差异。几种治疗方案和评估视力的不同标准导致难以产生选择正确治疗方法的证据。
