PDF(Pubmed)
Abstract：
Solitary fibrous tumor (SFT) of the central nervous system (previously called hemangiopericytoma) is a rare mesenchymal tumor. Malignant SFT has a tendency to recur after surgery and can metastasize to distant organs. Treatment options for metastatic disease are limited. This case demonstrated high expression of FAP (fibroblast activating protein) in all metastatic sites with Ga-FAPI positron emission tomography-computed tomography imaging. Subsequently, the patient was treated with Lu177-FAPI-targeted radionuclide therapy. There was significant clinical response. There was mild partial morphological response seen on follow-up imaging.
摘要：
中枢神经系统的孤立性纤维性肿瘤（SFT）（以前称为血管外皮细胞瘤）是一种罕见的间充质肿瘤。恶性SFT在手术后有复发的趋势，并且可以转移到远处的器官。转移性疾病的治疗选择是有限的。该病例在Ga-FAPI正电子发射断层扫描-计算机断层扫描成像的所有转移部位均显示FAP（成纤维细胞激活蛋白）高表达。随后，患者接受了Lu177-FAPI靶向放射性核素治疗.有显著的临床反应。在随访成像中观察到轻度的部分形态学反应。
