PDF(Pubmed)
Abstract：
UNASSIGNED: Testosterone treatment is employed in transgender men to help them affirm their gender. Our objective is to report the cases of 2 transgender men who received subdermal testosterone pellets as the mode of testosterone administration.
UNASSIGNED: Both patients presented for discussion of testosterone therapy. Patient 1 was a 47-year-old transgender male. He had bilateral mastectomy and total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO). Physical exam was significant for obesity. He was on injectable testosterone for 9 years and experienced voice deepening, facial hair growth, temporal hair thinning, and increased skin oiliness, but was interested in a long-acting testosterone formulation. Pellets were well tolerated, but the patient ultimately chose to return to injections. Patient 2 was a 20-year-old transgender male with no history of gender-affirming surgeries. Physical exam was pertinent for a thin, masculinized individual. He started on testosterone gel, but switched to weekly injections, on which he experienced voice deepening, increased skin oiliness and cessation of menses. Due to pain with injections and desire for a long-acting formulation, he elected to try pellets.
UNASSIGNED: The dose of testosterone pellets used in transgender men are similar to those employed for testosterone replacement in hypogonadal cisgender men.
UNASSIGNED: Subdermal testosterone pellets may be suitable as a means of delivering testosterone in transgender men, but the 2 cases reported here do not permit firm conclusions. Given the widespread use of testosterone for gender affirmation in transgender men, a prospective controlled study of subdermal testosterone pellets seems indicated.
UNASSIGNED: Both patients presented for discussion of testosterone therapy. Patient 1 was a 47-year-old transgender male. He had bilateral mastectomy and total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO). Physical exam was significant for obesity. He was on injectable testosterone for 9 years and experienced voice deepening, facial hair growth, temporal hair thinning, and increased skin oiliness, but was interested in a long-acting testosterone formulation. Pellets were well tolerated, but the patient ultimately chose to return to injections. Patient 2 was a 20-year-old transgender male with no history of gender-affirming surgeries. Physical exam was pertinent for a thin, masculinized individual. He started on testosterone gel, but switched to weekly injections, on which he experienced voice deepening, increased skin oiliness and cessation of menses. Due to pain with injections and desire for a long-acting formulation, he elected to try pellets.
UNASSIGNED: The dose of testosterone pellets used in transgender men are similar to those employed for testosterone replacement in hypogonadal cisgender men.
UNASSIGNED: Subdermal testosterone pellets may be suitable as a means of delivering testosterone in transgender men, but the 2 cases reported here do not permit firm conclusions. Given the widespread use of testosterone for gender affirmation in transgender men, a prospective controlled study of subdermal testosterone pellets seems indicated.
摘要：
■跨性别男性使用睾酮治疗来帮助他们确认自己的性别。我们的目标是报告2例接受皮下睾丸激素颗粒作为睾丸激素给药方式的变性男性。
■两名患者均提出讨论睾酮治疗。患者1是一名47岁的变性男性。他接受了双侧乳房切除术和全腹子宫切除术以及双侧附件卵巢切除术（TAH-BSO）。体检对肥胖有重要意义。他服用可注射睾丸激素已有9年，并经历了声音加深，面部毛发生长,颞叶毛发稀疏,增加皮肤油性，但对长效睾酮制剂感兴趣。颗粒耐受性良好，但病人最终选择了重新注射.患者2是一名20岁的变性男性，没有性别确认手术史。体检与瘦身有关，男性化的个人。他开始服用睾酮凝胶，但改为每周注射，他经历了声音的加深，增加皮肤油性和月经停止。由于注射疼痛和对长效制剂的渴望，他选择尝试颗粒。
■用于变性男性的睾酮颗粒的剂量与用于性腺机能减退男性的睾酮替代的剂量相似。
■皮下睾酮颗粒可能适合作为在变性男性中递送睾酮的一种手段，但是这里报道的两个案例不允许得出确切的结论。鉴于在变性男性中广泛使用睾丸激素来确认性别，一项针对皮下睾酮颗粒的前瞻性对照研究似乎表明.
■两名患者均提出讨论睾酮治疗。患者1是一名47岁的变性男性。他接受了双侧乳房切除术和全腹子宫切除术以及双侧附件卵巢切除术（TAH-BSO）。体检对肥胖有重要意义。他服用可注射睾丸激素已有9年，并经历了声音加深，面部毛发生长,颞叶毛发稀疏,增加皮肤油性，但对长效睾酮制剂感兴趣。颗粒耐受性良好，但病人最终选择了重新注射.患者2是一名20岁的变性男性，没有性别确认手术史。体检与瘦身有关，男性化的个人。他开始服用睾酮凝胶，但改为每周注射，他经历了声音的加深，增加皮肤油性和月经停止。由于注射疼痛和对长效制剂的渴望，他选择尝试颗粒。
■用于变性男性的睾酮颗粒的剂量与用于性腺机能减退男性的睾酮替代的剂量相似。
■皮下睾酮颗粒可能适合作为在变性男性中递送睾酮的一种手段，但是这里报道的两个案例不允许得出确切的结论。鉴于在变性男性中广泛使用睾丸激素来确认性别，一项针对皮下睾酮颗粒的前瞻性对照研究似乎表明.
