PDF(Pubmed)
Abstract：
UNASSIGNED: Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized.
UNASSIGNED: In Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk in Babies Learning Early Signs (MARBLES), two pregnancy cohorts of siblings of children with ASD, maternal urinary metals concentrations at two time points during pregnancy were measured using inductively coupled plasma mass spectrometry. At age three, clinicians assessed ASD with DSM-5 criteria. Using multivariable log binomial regression, we examined each metal for association with ASD status, adjusting for gestational age at urine sampling, child sex, maternal age, and maternal education, and meta-analyzed across the two cohorts.
UNASSIGNED: In EARLI (n=170) 17.6% of children were diagnosed with ASD, and an additional 43.5% were classified as having other non-neurotypical development (Non-TD). In MARBLES (n=156), 22.7% were diagnosed with ASD, while an additional 11.5% had Non-TD. In earlier pregnancy metals measures, having cadmium concentration over the level of detection was associated with 1.78 (1.19, 2.67) times higher risk of ASD, and 1.43 (1.06, 1.92) times higher risk of Non-TD. A doubling of early pregnancy cesium concentration was marginally associated with 1.81 (0.95, 3.42) times higher risk of ASD, and 1.58 (0.95, 2.63) times higher risk of Non-TD.
UNASSIGNED: Exposure in utero to elevated levels of cadmium and cesium, as measured in maternal urine collected during pregnancy, was associated with increased risk of developing ASD.
UNASSIGNED: In Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk in Babies Learning Early Signs (MARBLES), two pregnancy cohorts of siblings of children with ASD, maternal urinary metals concentrations at two time points during pregnancy were measured using inductively coupled plasma mass spectrometry. At age three, clinicians assessed ASD with DSM-5 criteria. Using multivariable log binomial regression, we examined each metal for association with ASD status, adjusting for gestational age at urine sampling, child sex, maternal age, and maternal education, and meta-analyzed across the two cohorts.
UNASSIGNED: In EARLI (n=170) 17.6% of children were diagnosed with ASD, and an additional 43.5% were classified as having other non-neurotypical development (Non-TD). In MARBLES (n=156), 22.7% were diagnosed with ASD, while an additional 11.5% had Non-TD. In earlier pregnancy metals measures, having cadmium concentration over the level of detection was associated with 1.78 (1.19, 2.67) times higher risk of ASD, and 1.43 (1.06, 1.92) times higher risk of Non-TD. A doubling of early pregnancy cesium concentration was marginally associated with 1.81 (0.95, 3.42) times higher risk of ASD, and 1.58 (0.95, 2.63) times higher risk of Non-TD.
UNASSIGNED: Exposure in utero to elevated levels of cadmium and cesium, as measured in maternal urine collected during pregnancy, was associated with increased risk of developing ASD.
摘要：
■自闭症谱系障碍（ASD）是一种普遍存在的异质性神经发育障碍。风险归因于遗传和产前环境因素，尽管环境因子的特征不完全。
■在早期自闭症风险纵向调查（EARLI）和婴儿学习早期体征（MARBLES）的自闭症风险标志物中，两个怀孕组有很高的ASD可能性，使用电感耦合等离子体质谱法测量孕妇在怀孕期间两个时间点的尿中金属浓度.三岁的时候,临床医生用DSM-5标准评估ASD。使用多变量对数二项回归，我们检查了每种金属与ASD状态的关联，在尿液取样时调整胎龄，儿童性,产妇年龄,和母亲教育，并对两个队列进行荟萃分析。
■在EARLI（n=170）中，17.6％的儿童被诊断为ASD，另外43.5%被归类为具有其他非神经典型发育(非TD)。在MARBLES（n=156）中，22.7%被诊断为ASD，而另外11.5%的人有非TD。在早期的怀孕金属措施中，镉浓度超过检测水平与ASD的1.78（1.19，2.67）倍风险相关，和非TD风险的1.43(1.06，1.92)倍。妊娠早期铯浓度的加倍与ASD的1.81（0.95，3.42）倍的风险略有相关，和1.58（0.95，2.63）倍的非TD风险。
■子宫内镉和铯含量升高，在怀孕期间收集的母体尿液中测量，与发展ASD的风险增加有关。
■在早期自闭症风险纵向调查（EARLI）和婴儿学习早期体征（MARBLES）的自闭症风险标志物中，两个怀孕组有很高的ASD可能性，使用电感耦合等离子体质谱法测量孕妇在怀孕期间两个时间点的尿中金属浓度.三岁的时候,临床医生用DSM-5标准评估ASD。使用多变量对数二项回归，我们检查了每种金属与ASD状态的关联，在尿液取样时调整胎龄，儿童性,产妇年龄,和母亲教育，并对两个队列进行荟萃分析。
■在EARLI（n=170）中，17.6％的儿童被诊断为ASD，另外43.5%被归类为具有其他非神经典型发育(非TD)。在MARBLES（n=156）中，22.7%被诊断为ASD，而另外11.5%的人有非TD。在早期的怀孕金属措施中，镉浓度超过检测水平与ASD的1.78（1.19，2.67）倍风险相关，和非TD风险的1.43(1.06，1.92)倍。妊娠早期铯浓度的加倍与ASD的1.81（0.95，3.42）倍的风险略有相关，和1.58（0.95，2.63）倍的非TD风险。
■子宫内镉和铯含量升高，在怀孕期间收集的母体尿液中测量，与发展ASD的风险增加有关。
