PDF(Pubmed)
Abstract：
To investigate the impact of a Ti-Sr-O technology, applied to either a turned surface or an SLA surface, on the mechanical robustness of osseointegration, benchmarked against the SLActive surface.
Ti discs (6.25-mm-diameter and 2-mm-thick) with three different surfaces were inserted on the proximal-anterior part of the tibial plateau of adult Swedish loop rabbits: (I) turned surface modified with Ti-Sr-O (turned + Ti-Sr-O), (II) SLA surface modified with Ti-Sr-O (SLA + Ti-Sr-O), and (III) SLActive surface (SLActive). Following a healing period of 2 weeks and 4 weeks, the pull-out (PO) force needed to detach the discs from the bone was assessed, as a surrogate of osseointegration.
The SLActive surface exhibited statistically significant higher median PO forces, compared with the SLA + Ti-Sr-O surfaces at both 2- and 4 weeks post-op (p > .05). In this study, no single turned + Ti-Sr-O surface disk was integrated.
The tested Ti-Sr-O technology failed to enhance osseointegration; however, this finding may be related to the inappropriateness of the rabbit tibia plateau model for assessing third-generation implant surface technologies, due to the limited diffusion and clearance at the disk-bone interface.
Ti discs (6.25-mm-diameter and 2-mm-thick) with three different surfaces were inserted on the proximal-anterior part of the tibial plateau of adult Swedish loop rabbits: (I) turned surface modified with Ti-Sr-O (turned + Ti-Sr-O), (II) SLA surface modified with Ti-Sr-O (SLA + Ti-Sr-O), and (III) SLActive surface (SLActive). Following a healing period of 2 weeks and 4 weeks, the pull-out (PO) force needed to detach the discs from the bone was assessed, as a surrogate of osseointegration.
The SLActive surface exhibited statistically significant higher median PO forces, compared with the SLA + Ti-Sr-O surfaces at both 2- and 4 weeks post-op (p > .05). In this study, no single turned + Ti-Sr-O surface disk was integrated.
The tested Ti-Sr-O technology failed to enhance osseointegration; however, this finding may be related to the inappropriateness of the rabbit tibia plateau model for assessing third-generation implant surface technologies, due to the limited diffusion and clearance at the disk-bone interface.
摘要：
目的：为了研究Ti-Sr-O技术的影响，应用于车削曲面或SLA曲面，关于骨整合的机械鲁棒性，以SLActive表面为基准。
方法：将具有三个不同表面的Ti盘（直径6.25毫米，厚度2毫米）插入成年瑞典圈兔胫骨平台的近端前部：（I）用Ti-Sr-O修饰的翻转表面（翻转Ti-Sr-O），(II)用Ti-Sr-O修饰的SLA表面(SLA+Ti-Sr-O),和(III)SLActive表面(SLActive)。经过2周和4周的愈合期，评估了将椎间盘从骨骼中分离所需的拔出力（PO），作为骨整合的替代品。
结果：SLActive表面显示出统计学上显着较高的中位数PO力，与术后2周和4周的SLA+Ti-Sr-O表面相比(p>.05)。在这项研究中,没有集成单车削+Ti-Sr-O表面盘。
结论：测试的Ti-Sr-O技术未能增强骨整合；然而，这一发现可能与兔胫骨平台模型不适合评估第三代植入物表面技术有关，由于椎间盘-骨界面的扩散和间隙有限。
方法：将具有三个不同表面的Ti盘（直径6.25毫米，厚度2毫米）插入成年瑞典圈兔胫骨平台的近端前部：（I）用Ti-Sr-O修饰的翻转表面（翻转Ti-Sr-O），(II)用Ti-Sr-O修饰的SLA表面(SLA+Ti-Sr-O),和(III)SLActive表面(SLActive)。经过2周和4周的愈合期，评估了将椎间盘从骨骼中分离所需的拔出力（PO），作为骨整合的替代品。
结果：SLActive表面显示出统计学上显着较高的中位数PO力，与术后2周和4周的SLA+Ti-Sr-O表面相比(p>.05)。在这项研究中,没有集成单车削+Ti-Sr-O表面盘。
结论：测试的Ti-Sr-O技术未能增强骨整合；然而，这一发现可能与兔胫骨平台模型不适合评估第三代植入物表面技术有关，由于椎间盘-骨界面的扩散和间隙有限。
