PDF(Pubmed)
Abstract：
Gastrointestinal pseudo-obstruction (GIPO) is a phenotype of the paraneoplastic neurological syndrome (PNS). We herein report a case of small-cell lung carcinoma (SCLC) with GIPO elicited by an immune checkpoint inhibitor (ICI). A 75-year-old man with SCLC developed intractable intestinal obstruction after receiving one course of anticancer drugs (durvalumab, etoposide, and carboplatin). The serum anti-Hu antibody (Hu-Ab) was positive, and the patient was diagnosed with GIPO. Corticosteroid treatment did not improve the GIPO, and the patient died. There are few reports of GIPO after ICI treatment in patients with lung cancer, so a further investigation will be required to elucidate the mechanism by which ICIs elicit PNS. Checking for neuronal antibodies may help identify patients with SCLC who are at risk of developing PNS due to ICI treatment.
摘要：
胃肠道假性梗阻（GIPO）是副肿瘤神经综合征（PNS）的表型。我们在此报告了由免疫检查点抑制剂（ICI）引起的GIPO小细胞肺癌（SCLC）的病例。一名75岁的SCLC患者在接受一个疗程的抗癌药物后出现了顽固性肠梗阻（durvalumab，依托泊苷,和卡铂）。血清抗Hu抗体(Hu-Ab)阳性,患者被诊断为GIPO。皮质类固醇治疗并没有改善GIPO，病人死了.肺癌患者ICI治疗后GIPO的报道很少，因此需要进一步的研究来阐明ICIs引发PNS的机制.检查神经元抗体可能有助于识别由于ICI治疗而有发生PNS风险的SCLC患者。
