Abstract：
In this narrative review, we present a comprehensive assessment on the putative roles of long non-coding RNAs (lncRNAs) in intermittent hypoxia (IH) and sleep apnea. Collectively, the evidence from cell culture, animal, and clinical research studies points to the functional involvement of lncRNAs in the pathogenesis, diagnosis, and potential treatment strategies for this highly prevalent disorder. Further research is clearly warranted to uncover the mechanistic pathways and to exploit the therapeutic potential of lncRNAs, thereby improving the management and outcomes of patients suffering from sleep apnea.
摘要：
在这篇叙述性评论中，我们对长链非编码RNA(lncRNA)在间歇性缺氧(IH)和睡眠呼吸暂停中的推定作用进行了全面评估.总的来说，细胞培养的证据,动物,临床研究指出lncRNAs在发病机制中的功能参与，诊断,以及这种高度流行的疾病的潜在治疗策略。进一步的研究显然有必要揭示机制途径并利用lncRNAs的治疗潜力，从而改善睡眠呼吸暂停患者的治疗和预后。
