Abstract：
OBJECTIVE: Nocturnal polyuria (NP) is one of the causes of nocturia that impairs quality of life. It is necessary to consider that NP is latent when the initial treatment for nocturia is unsatisfactory. Therefore, it is important to establish a treatment for NP based on the pathophysiology. We have previously reported the relationship between NP and fluctuation in blood pressure. The present study aimed to investigate the association between NP and 24-h blood pressure fluctuations in a multicenter prospective study.
METHODS: This study included male patients with lower urinary tract symptoms. We categorized the patients into the nonnocturnal polyuria (non-NP) group (≤0.33) and the NP group (>0.33) based on the nocturnal polyuria index from the frequency volume chart. We measured the 24-h diurnal blood pressure and compared the two groups.
RESULTS: Among 90 patients, 46 in the non-NP group and 44 in the NP group were included. There was no significant difference in the systolic and diastolic blood pressure during waking time between the two groups; however, the degree of systolic blood pressure reduction during sleep time in the NP group was significantly less than that in the non-NP group (p = 0.039). In the multivariate analysis, systolic BP during sleep was significantly associated with NP (OR 0.970, p = 0.028).
CONCLUSIONS: NP is associated with inadequate nocturnal blood pressure reduction in males, suggesting that reduction in nocturnal blood pressure may lead to improvement in nocturia.
METHODS: This study included male patients with lower urinary tract symptoms. We categorized the patients into the nonnocturnal polyuria (non-NP) group (≤0.33) and the NP group (>0.33) based on the nocturnal polyuria index from the frequency volume chart. We measured the 24-h diurnal blood pressure and compared the two groups.
RESULTS: Among 90 patients, 46 in the non-NP group and 44 in the NP group were included. There was no significant difference in the systolic and diastolic blood pressure during waking time between the two groups; however, the degree of systolic blood pressure reduction during sleep time in the NP group was significantly less than that in the non-NP group (p = 0.039). In the multivariate analysis, systolic BP during sleep was significantly associated with NP (OR 0.970, p = 0.028).
CONCLUSIONS: NP is associated with inadequate nocturnal blood pressure reduction in males, suggesting that reduction in nocturnal blood pressure may lead to improvement in nocturia.
摘要：
目的：夜尿症（NP）是影响生活质量的原因之一。当夜尿症的初始治疗不令人满意时，有必要考虑NP是潜在的。因此,重要的是建立基于病理生理学的NP治疗方法。我们以前报道过NP与血压波动之间的关系。本研究旨在调查NP与24小时血压波动之间的关系。
方法：本研究包括有下尿路症状的男性患者。我们根据频率容量图中的夜间多尿指数将患者分为非夜间多尿（非NP）组（≤0.33）和NP组（>0.33）。我们测量了24小时的昼夜血压，并比较了两组。
结果：在90例患者中，包括非NP组中的46例和NP组中的44例。苏醒时两组的收缩压和舒张压无显著差异;NP组睡眠时收缩压下降程度明显小于非NP组(p=0.039).在多变量分析中，睡眠时收缩压与NP显著相关(OR0.970,p=0.028).
结论：NP与男性夜间血压降低不足有关，提示夜间血压的降低可能导致夜尿症的改善。
方法：本研究包括有下尿路症状的男性患者。我们根据频率容量图中的夜间多尿指数将患者分为非夜间多尿（非NP）组（≤0.33）和NP组（>0.33）。我们测量了24小时的昼夜血压，并比较了两组。
结果：在90例患者中，包括非NP组中的46例和NP组中的44例。苏醒时两组的收缩压和舒张压无显著差异;NP组睡眠时收缩压下降程度明显小于非NP组(p=0.039).在多变量分析中，睡眠时收缩压与NP显著相关(OR0.970,p=0.028).
结论：NP与男性夜间血压降低不足有关，提示夜间血压的降低可能导致夜尿症的改善。
