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Abstract：
BACKGROUND: Cutaneous allodynia is highly prevalent among migraineurs and is associated with a poor prognosis. The Allodynia Symptom Checklist (ASC-12) is a comprehensive questionnaire to identify the presence and severity of allodynia. Our aim was to translate and adapt the ASC-12 to German and evaluate its measurement properties.
METHODS: Following the COSMIN guidelines, 80 migraine patients were enrolled in the study to evaluate the stages of translation (n=30) and measurement propriety assessment (n=50), respectively. After reaching a final version, the German ASC-12 was assessed for structural validity, internal consistency, test-retest reliability, construct validity and absolute agreement, using mechanical and thermal pain thresholds as reference method.
RESULTS: The German version of the ASC-12 presented an adequate structural validity compatible with the original version of the questionnaire. Its internal consistency ranged from 0.70 to 0.80 considering the total score and the thermic, static and dynamic mechanic subdomains. The total score presented excellent reliability (ICC: 0.85) with a standard error of measurement of 1.15 points and smallest detectable change of 3.40 points. ASC-12 total scores were correlated with headache intensity (r=0.38, p=0.004), headache disability (r=0.37, p=0.004) and cold pain thresholds (r=0.28, p=0.025). The thermic allodynia ASC-12 scores were correlated with cold (r=0.36, p=0.005) and heat (r=-0.30, p=0.010) pain thresholds, while the static mechanical allodynia ASC-12 scores correlated with mechanical pain threshold (r=0.29, p=0.019) and with mechanical pain sensitivity (r=0.24 to 0.28, p< 0.045). Despite no significant bias between methods, quantitative sensory testing (QST) results and ASC-12 scores tend to disagree.
CONCLUSIONS: The German version of the ASC-12 is available for research and clinical settings and presented adequate measurement proprieties, as the original version. Despite the correlation between the ASC-12 and QST, one method cannot be replaced by the other.
METHODS: Following the COSMIN guidelines, 80 migraine patients were enrolled in the study to evaluate the stages of translation (n=30) and measurement propriety assessment (n=50), respectively. After reaching a final version, the German ASC-12 was assessed for structural validity, internal consistency, test-retest reliability, construct validity and absolute agreement, using mechanical and thermal pain thresholds as reference method.
RESULTS: The German version of the ASC-12 presented an adequate structural validity compatible with the original version of the questionnaire. Its internal consistency ranged from 0.70 to 0.80 considering the total score and the thermic, static and dynamic mechanic subdomains. The total score presented excellent reliability (ICC: 0.85) with a standard error of measurement of 1.15 points and smallest detectable change of 3.40 points. ASC-12 total scores were correlated with headache intensity (r=0.38, p=0.004), headache disability (r=0.37, p=0.004) and cold pain thresholds (r=0.28, p=0.025). The thermic allodynia ASC-12 scores were correlated with cold (r=0.36, p=0.005) and heat (r=-0.30, p=0.010) pain thresholds, while the static mechanical allodynia ASC-12 scores correlated with mechanical pain threshold (r=0.29, p=0.019) and with mechanical pain sensitivity (r=0.24 to 0.28, p< 0.045). Despite no significant bias between methods, quantitative sensory testing (QST) results and ASC-12 scores tend to disagree.
CONCLUSIONS: The German version of the ASC-12 is available for research and clinical settings and presented adequate measurement proprieties, as the original version. Despite the correlation between the ASC-12 and QST, one method cannot be replaced by the other.
摘要：
背景：皮肤异常性疼痛在偏头痛患者中非常普遍，并且与不良预后相关。异常性疼痛症状清单（ASC-12）是一项全面的问卷，用于确定异常性疼痛的存在和严重程度。我们的目标是将ASC-12翻译成德语，并对其测量特性进行评估。
方法：遵循COSMIN指南，80名偏头痛患者被纳入研究，以评估翻译阶段（n=30）和测量适当性评估（n=50），分别。到达最终版本后，德国ASC-12进行了结构有效性评估，内部一致性，测试-重测可靠性，构建有效性和绝对一致性，以机械痛阈值和热痛阈值为参考方法。
结果：ASC-12的德语版本提供了与原始版本的问卷兼容的足够的结构效度。考虑到总分和热，其内部一致性范围为0.70至0.80，静态和动态机械子域。总分具有优异的可靠性(ICC:0.85),测量的标准误差为1.15分,可检测的最小变化为3.40分。ASC-12总分与头痛强度相关(r=0.38,p=0.004),头痛障碍（r=0.37，p=0.004）和冷痛阈值（r=0.28，p=0.025）。热异常性疼痛ASC-12评分与冷（r=0.36，p=0.005）和热（r=-0.30，p=0.010）疼痛阈值相关，而静态机械性异常疼痛ASC-12评分与机械性疼痛阈值（r=0.29，p=0.019）和机械性疼痛敏感性（r=0.24至0.28，p<0.045）相关。尽管方法之间没有明显的偏差，定量感官测试(QST)结果与ASC-12评分趋于不一致。
结论：ASC-12的德语版本可用于研究和临床设置，并提供了足够的测量特性，作为原始版本。尽管ASC-12和QST之间存在相关性，一种方法不能被另一种方法代替。
方法：遵循COSMIN指南，80名偏头痛患者被纳入研究，以评估翻译阶段（n=30）和测量适当性评估（n=50），分别。到达最终版本后，德国ASC-12进行了结构有效性评估，内部一致性，测试-重测可靠性，构建有效性和绝对一致性，以机械痛阈值和热痛阈值为参考方法。
结果：ASC-12的德语版本提供了与原始版本的问卷兼容的足够的结构效度。考虑到总分和热，其内部一致性范围为0.70至0.80，静态和动态机械子域。总分具有优异的可靠性(ICC:0.85),测量的标准误差为1.15分,可检测的最小变化为3.40分。ASC-12总分与头痛强度相关(r=0.38,p=0.004),头痛障碍（r=0.37，p=0.004）和冷痛阈值（r=0.28，p=0.025）。热异常性疼痛ASC-12评分与冷（r=0.36，p=0.005）和热（r=-0.30，p=0.010）疼痛阈值相关，而静态机械性异常疼痛ASC-12评分与机械性疼痛阈值（r=0.29，p=0.019）和机械性疼痛敏感性（r=0.24至0.28，p<0.045）相关。尽管方法之间没有明显的偏差，定量感官测试(QST)结果与ASC-12评分趋于不一致。
结论：ASC-12的德语版本可用于研究和临床设置，并提供了足够的测量特性，作为原始版本。尽管ASC-12和QST之间存在相关性，一种方法不能被另一种方法代替。
