Abstract：
Bio-based drug delivery devices have gained enormous interest in the biomedical field due to their biocompatible attributes. Extensive research is being conducted on chitosan-based devices for drug delivery applications. Chitosan being hydrophobic under neutral conditions makes it difficult to interact with a polar drug of curcumin. We tended to make it polar through sol-gel synthesis and modification via PEGylation, alkaline hydrolysis, and aminolysis. Such alterations could make the chitosan-based scaffolds porous, hydrophilic, amino-functionalized, and pH-responsive. The ninhydrin assay confirmed that a successful aminolysis occurred, and the chemical interaction among the precursors was explained under infrared spectroscopy. The scanning morphology of the optimum aminolyzed membrane appeared to be porous with an average pore size of 320 ± 20 nm. The aminolyzed chitosan membrane was found thermally stable up to 310 °C, hydrophilic with a water contact angle of 23.4°, moderate flowablity, and porous (97 ± 5 %, w/w) against ethanol. The curcumin-loaded chitosan membrane expressed the UV-protection behavior of 99 %. The curcumin-loading and release phenomena were found pH-responsive. The curcumin release results were evaluated through specific kinetic models. This study could be the first report on the amphiphilic, porous, and swellable drug-loaded gelatin/chitosan membrane with pH-responsive loading and release of curcumin for potential drug delivery applications.
摘要：
基于生物的药物递送装置由于其生物相容性而在生物医学领域获得了极大的兴趣。正在对用于药物递送应用的基于壳聚糖的装置进行广泛的研究。壳聚糖在中性条件下是疏水性的,使得难以与姜黄素的极性药物相互作用。我们倾向于通过溶胶-凝胶合成和通过聚乙二醇化改性使其具有极性，碱性水解，和氨解。这种改变可以使基于壳聚糖的支架多孔，亲水性,氨基官能化，和pH响应。进行了三三酮测定，证实了成功的氨解发生，并在红外光谱下解释了前驱体之间的化学相互作用。最佳氨解膜的扫描形态似乎是多孔的，平均孔径为320±20nm。发现氨基分解的壳聚糖膜在高达310°C的温度下是热稳定的，亲水，水接触角为23.4°，中等流动性,多孔(97±5%，w/w)对乙醇。负载姜黄素的壳聚糖膜表现出99%的UV防护行为。发现姜黄素负载和释放现象具有pH响应性。通过特定的动力学模型评估姜黄素释放结果。这项研究可能是关于两亲性的第一份报告，多孔，和可溶胀的载药明胶/壳聚糖膜，具有pH响应性负载和姜黄素的释放，用于潜在的药物递送应用。
