PDF(Pubmed)
Abstract：
BACKGROUND: Impairment of left ventricular (LV) longitudinal function is an early marker of systolic dysfunction in hypertrophic cardiomyopathy (HCM). Aortic annular plane systolic excursion (AAPSE) is a measure of LV longitudinal function in people that has not been evaluated in cats.
OBJECTIVE: Aortic annular plane systolic excursion is lower in cats with HCM compared to control cats, and cats in stage C have the lowest AAPSE.
METHODS: One hundred seventy-five cats: 60 normal, 61 HCM stage B and 54 HCM stage C cats.
METHODS: Multicenter retrospective case-control study. Electronic medical records from 4 referral hospitals were reviewed for cats diagnosed with HCM and normal cats. HCM was defined as LV wall thickness ≥6 mm and normal cats ≤5 mm. M-mode bisecting the aorta in right parasternal short-axis view was used to measure AAPSE.
RESULTS: Aortic annular plane systolic excursion was lower in HCM cats compared to normal cats (3.9 ± 0.9 mm versus 4.6 ± 0.9 mm, P < .001) and was lowest in HCM stage C (2.4 ± 0.6 mm, P < .001). An AAPSE <2.9 mm gave a sensitivity of 83% (95% CI 71%-91%) and specificity of 92% (95% CI 82%-97%) to differentiate HCM stage C from stage B. AAPSE correlated with mitral annular plane systolic excursion (r = .6 [.4-.7], P < .001), and atrial fractional shortening (r = .6 [.5-.7], P < .001), but showed no correlation with LV fractional shortening.
CONCLUSIONS: Aortic annular plane systolic excursion is an easily acquired echocardiographic variable and might be a new measurement of LV systolic performance in cats with HCM.
OBJECTIVE: Aortic annular plane systolic excursion is lower in cats with HCM compared to control cats, and cats in stage C have the lowest AAPSE.
METHODS: One hundred seventy-five cats: 60 normal, 61 HCM stage B and 54 HCM stage C cats.
METHODS: Multicenter retrospective case-control study. Electronic medical records from 4 referral hospitals were reviewed for cats diagnosed with HCM and normal cats. HCM was defined as LV wall thickness ≥6 mm and normal cats ≤5 mm. M-mode bisecting the aorta in right parasternal short-axis view was used to measure AAPSE.
RESULTS: Aortic annular plane systolic excursion was lower in HCM cats compared to normal cats (3.9 ± 0.9 mm versus 4.6 ± 0.9 mm, P < .001) and was lowest in HCM stage C (2.4 ± 0.6 mm, P < .001). An AAPSE <2.9 mm gave a sensitivity of 83% (95% CI 71%-91%) and specificity of 92% (95% CI 82%-97%) to differentiate HCM stage C from stage B. AAPSE correlated with mitral annular plane systolic excursion (r = .6 [.4-.7], P < .001), and atrial fractional shortening (r = .6 [.5-.7], P < .001), but showed no correlation with LV fractional shortening.
CONCLUSIONS: Aortic annular plane systolic excursion is an easily acquired echocardiographic variable and might be a new measurement of LV systolic performance in cats with HCM.
摘要：
背景：左心室（LV）纵向功能受损是肥厚型心肌病（HCM）收缩功能障碍的早期标志。主动脉瓣环平面收缩期偏移（AAPSE）是尚未在猫中评估的人的LV纵向功能的量度。
目的：与对照猫相比，患有HCM的猫的主动脉环平面收缩期偏移较低，C阶段的猫的AAPSE最低。
方法：一百七十五只猫：60只正常，61只HCMB期猫和54只HCMC期猫。
方法：多中心回顾性病例对照研究。对于诊断为HCM的猫和正常猫，对4家转诊医院的电子病历进行了审查。HCM定义为LV壁厚≥6mm，正常猫≤5mm。在右胸骨旁短轴视图中，将主动脉平分的M模式用于测量AAPSE。
结果：与正常猫相比，HCM猫的主动脉瓣环平面收缩期偏移较低（3.9±0.9mm对4.6±0.9mm，P<.001），在HCM阶段C中最低（2.4±0.6mm，P<.001)。AAPSE<2.9mm对区分HCMC期和B期的敏感性为83％（95％CI71％-91％），特异性为92％（95％CI82％-97％）。AAPSE与二尖瓣环平面收缩期偏移相关（r=.6[.4-.7]，P<.001),和心房缩短分数(r=.6[.5-.7]，P<.001),但与LV缩短率无相关性。
结论：主动脉瓣环平面收缩偏移是一个容易获得的超声心动图变量，可能是HCM猫左心室收缩性能的新测量。
目的：与对照猫相比，患有HCM的猫的主动脉环平面收缩期偏移较低，C阶段的猫的AAPSE最低。
方法：一百七十五只猫：60只正常，61只HCMB期猫和54只HCMC期猫。
方法：多中心回顾性病例对照研究。对于诊断为HCM的猫和正常猫，对4家转诊医院的电子病历进行了审查。HCM定义为LV壁厚≥6mm，正常猫≤5mm。在右胸骨旁短轴视图中，将主动脉平分的M模式用于测量AAPSE。
结果：与正常猫相比，HCM猫的主动脉瓣环平面收缩期偏移较低（3.9±0.9mm对4.6±0.9mm，P<.001），在HCM阶段C中最低（2.4±0.6mm，P<.001)。AAPSE<2.9mm对区分HCMC期和B期的敏感性为83％（95％CI71％-91％），特异性为92％（95％CI82％-97％）。AAPSE与二尖瓣环平面收缩期偏移相关（r=.6[.4-.7]，P<.001),和心房缩短分数(r=.6[.5-.7]，P<.001),但与LV缩短率无相关性。
结论：主动脉瓣环平面收缩偏移是一个容易获得的超声心动图变量，可能是HCM猫左心室收缩性能的新测量。
