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Abstract：
Nuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR in a given cancer subtype is only one component of a larger transcriptional machinery that is controlled by multiple associated NRs and transcription factors. Additionally, their ability to regulate and to be regulated by molecules of non‑coding RNAs, microRNAs as well as long non‑coding RNAs, is opening new scenarios for understanding the role of NRs in cancer initiation and progression. In the present review, the authors aimed to outline the reciprocal interactions that exist between the main NRs and long non‑coding RNAs in different tumor diseases, to suggest new diagnostic biomarkers as well as therapeutic strategies for these tumors.
摘要：
核受体(NRs)是参与正常细胞生理学的不同方面的转录调节因子。它们的失调与异常表达有关，基因突变和/或表观遗传改变可能与各种人类疾病的发病机理有关，尤其是在癌症中。特别是,涉及NR介导的癌症的发生和发展的复杂基因组网络已被强调。先进的基因组技术已经使得有可能理解在给定的癌症亚型中任何特定NR的表达仅仅是由多个相关的NR和转录因子控制的更大的转录机制的一个组分。此外,它们调节和被非编码RNA分子调节的能力，microRNA以及长链非编码RNA，正在为理解NRs在癌症发生和进展中的作用开辟新的方案。在本次审查中，作者旨在概述不同肿瘤疾病中主要NRs和长链非编码RNA之间存在的相互作用，提出新的诊断生物标志物以及这些肿瘤的治疗策略。
