PDF(Pubmed)
Abstract：
UNASSIGNED: One of the core features of autism spectrum disorder (ASD) is restricted, repetitive patterns of behavior, interests and activities (RRBs). RRBs are known to adversely affect cognition and adaptive functioning. We explored the relationship of RRBs with cognition and adaptive functioning in children with ASD in an Asian setting.
UNASSIGNED: This cross-sectional study was conducted at a tertiary developmental pediatrics center in Singapore from September 2019 to October 2021. Parent-child dyads (parents and their children ≤7 years old diagnosed with ASD) were recruited. Parents completed the Repetitive Behavior Questionnaire-2 (RBQ-2), which reports total score and two subscales - Motor/Sensory Behaviors (RBQ-2 MS) and Rigidity/Routines/Preoccupation with Restricted Interests (RBQ-2 RRPRI). Standardized assessments included Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS-II). Data analysis utilized descriptive statistics and Pearson\'s correlation.
UNASSIGNED: Parents of 113 children [75.2% male, mean (SD) age 5.0 (1.2) years] participated. Median (IQR) RBQ-2 score was 29.0 (11.0). Significant negative correlations (adjusted for age, gender and family history of ASD) were observed for total RBQ-2 scores with MSEL ELC scores (r = -0.248, n = 101, p = 0.014) and VABS-II ABC scores (r = -0.281, n = 88, p = 0.009). Specifically, these correlations of fair strength were seen only with the RBQ-2 MS subscale for both ELC (r = -0.321, n = 101, p = 0.001) and ABC (r = -0.3478, n = 88, p = 0.001).
UNASSIGNED: In children with ASD, severity of RRBs correlated with adverse cognition and adaptive functioning measures in our study, consistent with Western literature. While our study does not show causality, it adds to literature serving as a foundation for further research for both clinicians and researchers to target RRBs in improving outcomes with children in ASD.
UNASSIGNED: This cross-sectional study was conducted at a tertiary developmental pediatrics center in Singapore from September 2019 to October 2021. Parent-child dyads (parents and their children ≤7 years old diagnosed with ASD) were recruited. Parents completed the Repetitive Behavior Questionnaire-2 (RBQ-2), which reports total score and two subscales - Motor/Sensory Behaviors (RBQ-2 MS) and Rigidity/Routines/Preoccupation with Restricted Interests (RBQ-2 RRPRI). Standardized assessments included Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS-II). Data analysis utilized descriptive statistics and Pearson\'s correlation.
UNASSIGNED: Parents of 113 children [75.2% male, mean (SD) age 5.0 (1.2) years] participated. Median (IQR) RBQ-2 score was 29.0 (11.0). Significant negative correlations (adjusted for age, gender and family history of ASD) were observed for total RBQ-2 scores with MSEL ELC scores (r = -0.248, n = 101, p = 0.014) and VABS-II ABC scores (r = -0.281, n = 88, p = 0.009). Specifically, these correlations of fair strength were seen only with the RBQ-2 MS subscale for both ELC (r = -0.321, n = 101, p = 0.001) and ABC (r = -0.3478, n = 88, p = 0.001).
UNASSIGNED: In children with ASD, severity of RRBs correlated with adverse cognition and adaptive functioning measures in our study, consistent with Western literature. While our study does not show causality, it adds to literature serving as a foundation for further research for both clinicians and researchers to target RRBs in improving outcomes with children in ASD.
摘要：
■自闭症谱系障碍（ASD）的核心特征之一受到限制，重复的行为模式，兴趣和活动(RRB)。已知RRB不利地影响认知和适应性功能。我们探讨了亚洲背景下ASD儿童RRB与认知和适应功能的关系。
■这项横断面研究于2019年9月至2021年10月在新加坡的三级发育儿科中心进行。招募亲子关系（父母及其子女诊断为ASD≤7岁）。父母填写了重复行为问卷-2(RBQ-2)，报告总分和两个分量表-运动/感觉行为（RBQ-2MS）和刚性/常规/关注限制性兴趣（RBQ-2RRPRI）。标准化评估包括Mullen早期学习量表（MSEL）和Vineland自适应行为量表（VABS-II）。数据分析利用描述性统计和皮尔逊相关性。
■113个孩子的父母[75.2%为男性，平均（SD）年龄5.0（1.2）岁]。RBQ-2评分中位数（IQR）为29.0（11.0）。显著负相关(根据年龄调整，性别和ASD家族史）的总RBQ-2评分，MSELELC评分（r=-0.248，n=101，p=0.014）和VABS-IIABC评分（r=-0.281，n=88，p=0.009）。具体来说,仅在ELC(r=-0.321,n=101,p=0.001)和ABC(r=-0.3478,n=88,p=0.001)的RBQ-2MS分量表的基础上观察到这些公平强度的相关性.
■在患有ASD的儿童中，在我们的研究中，RRB的严重程度与不良认知和适应性功能测量相关，与西方文学一致。虽然我们的研究没有显示因果关系，它增加了文献作为进一步研究的基础,为临床医生和研究人员以RRB为目标改善ASD儿童结局.
■这项横断面研究于2019年9月至2021年10月在新加坡的三级发育儿科中心进行。招募亲子关系（父母及其子女诊断为ASD≤7岁）。父母填写了重复行为问卷-2(RBQ-2)，报告总分和两个分量表-运动/感觉行为（RBQ-2MS）和刚性/常规/关注限制性兴趣（RBQ-2RRPRI）。标准化评估包括Mullen早期学习量表（MSEL）和Vineland自适应行为量表（VABS-II）。数据分析利用描述性统计和皮尔逊相关性。
■113个孩子的父母[75.2%为男性，平均（SD）年龄5.0（1.2）岁]。RBQ-2评分中位数（IQR）为29.0（11.0）。显著负相关(根据年龄调整，性别和ASD家族史）的总RBQ-2评分，MSELELC评分（r=-0.248，n=101，p=0.014）和VABS-IIABC评分（r=-0.281，n=88，p=0.009）。具体来说,仅在ELC(r=-0.321,n=101,p=0.001)和ABC(r=-0.3478,n=88,p=0.001)的RBQ-2MS分量表的基础上观察到这些公平强度的相关性.
■在患有ASD的儿童中，在我们的研究中，RRB的严重程度与不良认知和适应性功能测量相关，与西方文学一致。虽然我们的研究没有显示因果关系，它增加了文献作为进一步研究的基础,为临床医生和研究人员以RRB为目标改善ASD儿童结局.
