Abstract:
Gut inflammation and defect in the gut mucosal barrier appear to have a correlation with skin diseases and vice versa. The coexistence of hereditary ichthyosis with active colitis has never been reported. We present a 17-year-old female with ichthyosis since birth, abdomen pain for 3 months, with acute colitis. After the initial diagnosis, the patient was started on antituberculous therapy (ATT), steroids, and mesalamine. She followed up with us for 1 year where there was resolution of symptoms. Steroids were stopped after 16 weeks, mesalamine was stopped after 20 weeks in view of low absolute neutrophil counts and ATT was stopped after 1 year. She was asymptomatic post 18 months of stopping ATT.
摘要:
肠道炎症和肠粘膜屏障缺陷似乎与皮肤疾病有关,反之亦然。遗传性鱼鳞病与活动性结肠炎的共存从未被报道。我们介绍了一名17岁的女性,自出生以来患有鱼鳞病,腹痛3个月,急性结肠炎。初步诊断后,患者开始接受抗结核治疗(ATT),类固醇,还有美沙拉嗪.她对我们进行了1年的随访,症状得到了缓解。16周后停用类固醇,鉴于绝对中性粒细胞计数较低,美沙拉嗪在20周后停止,ATT在1年后停止。她在停止ATT18个月后无症状。