PDF(Pubmed)
Abstract：
UNASSIGNED: Ameloblastoma is a benign tumour of odontogenic epithelial origin arising from enamel organ tissue that has not undergone differentiation to the point of hard tissue formation.
UNASSIGNED: This study was conducted with an aim to provide a baseline data to analyse whether various histopathological variants of ameloblastoma satisfies all the characteristic histopathological features of Vickers and Gorlin criteria.
UNASSIGNED: A retrospective study of 25 cases of intraosseous ameloblastoma was carried out in the Department of Oral Pathology and Microbiology in accordance with the Institutional Ethics Committee.
UNASSIGNED: Histopathological slides of ameloblastoma subtypes were analysed microscopically to assess Vickers and Gorlin criteria.
UNASSIGNED: Statistical analysis was done using the Chi-square test. A P- value of < 0.05 was set for statistical significance.
UNASSIGNED: Presence of hyperchromatic nuclei was seen in all the variants (100%), except for the desmoplastic variant which showed only 60% positivity. Basal cell palisading, reverse polarity and subnuclear vacuolization were seen predominantly only in acanthomatous (100%), and follicular variants (83%).
UNASSIGNED: Vickers and Gorlin criteria have become an integral part of diagnosis of histopathological subtypes of ameloblastoma and should be applied vigilantly in the diagnosis as these may not always fulfill all the gold standard criteria when individual subtypes are assessed.
UNASSIGNED: This study was conducted with an aim to provide a baseline data to analyse whether various histopathological variants of ameloblastoma satisfies all the characteristic histopathological features of Vickers and Gorlin criteria.
UNASSIGNED: A retrospective study of 25 cases of intraosseous ameloblastoma was carried out in the Department of Oral Pathology and Microbiology in accordance with the Institutional Ethics Committee.
UNASSIGNED: Histopathological slides of ameloblastoma subtypes were analysed microscopically to assess Vickers and Gorlin criteria.
UNASSIGNED: Statistical analysis was done using the Chi-square test. A P- value of < 0.05 was set for statistical significance.
UNASSIGNED: Presence of hyperchromatic nuclei was seen in all the variants (100%), except for the desmoplastic variant which showed only 60% positivity. Basal cell palisading, reverse polarity and subnuclear vacuolization were seen predominantly only in acanthomatous (100%), and follicular variants (83%).
UNASSIGNED: Vickers and Gorlin criteria have become an integral part of diagnosis of histopathological subtypes of ameloblastoma and should be applied vigilantly in the diagnosis as these may not always fulfill all the gold standard criteria when individual subtypes are assessed.
摘要：
■成釉细胞瘤是牙源性上皮起源的良性肿瘤，起源于釉质器官组织，尚未分化为硬组织形成点。
■进行这项研究的目的是提供基线数据，以分析成釉细胞瘤的各种组织病理学变异是否满足Vickers和Gorlin标准的所有特征性组织病理学特征。
■根据机构伦理委员会，在口腔病理学和微生物学系进行了25例骨内成釉细胞瘤的回顾性研究。
■用显微镜分析成釉细胞瘤亚型的组织病理学切片以评估Vickers和Gorlin标准。
使用卡方检验进行统计分析。P-值<0.05被设定为具有统计学意义。
■在所有变体（100％）中都看到了超色核的存在，除了促纤维化变体仅显示60％的阳性。基底细胞栅栏，反极性和核下空泡化主要只见于棘皮瘤（100%），和卵泡变异（83％）。
Vickers和Gorlin标准已成为成釉细胞瘤组织病理学亚型诊断中不可或缺的一部分，应警惕地应用于诊断，因为在评估单个亚型时，这些标准可能并不总是满足所有黄金标准。
■进行这项研究的目的是提供基线数据，以分析成釉细胞瘤的各种组织病理学变异是否满足Vickers和Gorlin标准的所有特征性组织病理学特征。
■根据机构伦理委员会，在口腔病理学和微生物学系进行了25例骨内成釉细胞瘤的回顾性研究。
■用显微镜分析成釉细胞瘤亚型的组织病理学切片以评估Vickers和Gorlin标准。
使用卡方检验进行统计分析。P-值<0.05被设定为具有统计学意义。
■在所有变体（100％）中都看到了超色核的存在，除了促纤维化变体仅显示60％的阳性。基底细胞栅栏，反极性和核下空泡化主要只见于棘皮瘤（100%），和卵泡变异（83％）。
Vickers和Gorlin标准已成为成釉细胞瘤组织病理学亚型诊断中不可或缺的一部分，应警惕地应用于诊断，因为在评估单个亚型时，这些标准可能并不总是满足所有黄金标准。
