Abstract：
UNASSIGNED: Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder causing abdominal pain, altered bowel habits and bloating without structural issues. Gallbladder dysfunction may be linked to IBS due to disrupted cholecystokinin release. This study aims to assess gallbladder function and related hemodynamic parameters using Doppler ultrasound in IBS before and after meals.
UNASSIGNED: In this case-control study, we investigated gallbladder function differences between constipation-predominant IBS (C-IBS) patients and healthy volunteers. Participants underwent ultrasonography to measure gallbladder parameters before and after consuming a predefined meal. Gallbladder volume, wall thickness and resistance index (RI) of cystic and superior mesenteric arteries (SMA) were assessed. Student t-test and paired t-test were used to compare case and control groups and pre- and post-meal data, respectively.
UNASSIGNED: A total of 34 people (18 C-IBS and 16 healthy control) were included. The mean (Standard deviation) of gallbladder fasting volume was measured 24.74 (8.85) and 29.73 (9.65) cubic millimeter for case and controls, respectively. Postprandial volume was 11.34 (5.66) and 16.9 (6.16) cubic millimeter for case and controls respectively. We observed a statistically significant difference in emptying fractions (EF) between groups (p value = 0.009). IBS patients had a smaller fasting SMA RI (p value = 0.016) but the fraction of change after meal was not significant (p value = 0.10). The cystic artery RI did not reach statistical significance between the fasting and post-meal values (p value = 0.067).
UNASSIGNED: IBS patients have a higher emptying fraction and lower change in SMA RI compared to healthy controls. Further studies with larger sample size, inclusion of patients with different coexisting conditions and subtypes of IBS and combining colon transit study with gallbladder ejection fraction evaluation can be used to further provide more meaning to this study.
UNASSIGNED: In this case-control study, we investigated gallbladder function differences between constipation-predominant IBS (C-IBS) patients and healthy volunteers. Participants underwent ultrasonography to measure gallbladder parameters before and after consuming a predefined meal. Gallbladder volume, wall thickness and resistance index (RI) of cystic and superior mesenteric arteries (SMA) were assessed. Student t-test and paired t-test were used to compare case and control groups and pre- and post-meal data, respectively.
UNASSIGNED: A total of 34 people (18 C-IBS and 16 healthy control) were included. The mean (Standard deviation) of gallbladder fasting volume was measured 24.74 (8.85) and 29.73 (9.65) cubic millimeter for case and controls, respectively. Postprandial volume was 11.34 (5.66) and 16.9 (6.16) cubic millimeter for case and controls respectively. We observed a statistically significant difference in emptying fractions (EF) between groups (p value = 0.009). IBS patients had a smaller fasting SMA RI (p value = 0.016) but the fraction of change after meal was not significant (p value = 0.10). The cystic artery RI did not reach statistical significance between the fasting and post-meal values (p value = 0.067).
UNASSIGNED: IBS patients have a higher emptying fraction and lower change in SMA RI compared to healthy controls. Further studies with larger sample size, inclusion of patients with different coexisting conditions and subtypes of IBS and combining colon transit study with gallbladder ejection fraction evaluation can be used to further provide more meaning to this study.
摘要：
肠易激综合征（IBS）是一种常见的胃肠道疾病，引起腹痛，改变排便习惯和腹胀没有结构性问题。由于胆囊收缩素释放中断，胆囊功能障碍可能与IBS有关。本研究旨在在餐前和餐后使用多普勒超声评估IBS的胆囊功能和相关血液动力学参数。
■在本病例对照研究中，我们调查了便秘型IBS(C-IBS)患者和健康志愿者的胆囊功能差异.参与者在食用预定义膳食之前和之后接受超声检查以测量胆囊参数。胆囊体积,评估囊性和肠系膜上动脉（SMA）的壁厚和阻力指数（RI）。采用学生t检验和配对t检验比较病例组和对照组以及餐前和餐后数据,分别。
■共纳入34人（18例C-IBS和16例健康对照）。病例和对照组的胆囊空腹体积的平均值（标准偏差）分别为24.74（8.85）和29.73（9.65）立方毫米，分别。病例和对照组的餐后容积分别为11.34（5.66）和16.9（6.16）立方毫米。我们观察到两组之间的排空分数（EF）具有统计学上的显着差异（p值=0.009）。IBS患者的空腹SMARI较小（p值=0.016），但餐后变化的分数不显着（p值=0.10）。胆囊动脉RI在空腹和餐后值之间没有达到统计学意义（p值=0.067）。
■与健康对照相比，IBS患者具有更高的排空分数和更低的SMARI变化。更大样本量的进一步研究，纳入不同并存情况和亚型的IBS患者，并结合结肠传输研究和胆囊射血分数评估可进一步为本研究提供更多意义。
■在本病例对照研究中，我们调查了便秘型IBS(C-IBS)患者和健康志愿者的胆囊功能差异.参与者在食用预定义膳食之前和之后接受超声检查以测量胆囊参数。胆囊体积,评估囊性和肠系膜上动脉（SMA）的壁厚和阻力指数（RI）。采用学生t检验和配对t检验比较病例组和对照组以及餐前和餐后数据,分别。
■共纳入34人（18例C-IBS和16例健康对照）。病例和对照组的胆囊空腹体积的平均值（标准偏差）分别为24.74（8.85）和29.73（9.65）立方毫米，分别。病例和对照组的餐后容积分别为11.34（5.66）和16.9（6.16）立方毫米。我们观察到两组之间的排空分数（EF）具有统计学上的显着差异（p值=0.009）。IBS患者的空腹SMARI较小（p值=0.016），但餐后变化的分数不显着（p值=0.10）。胆囊动脉RI在空腹和餐后值之间没有达到统计学意义（p值=0.067）。
■与健康对照相比，IBS患者具有更高的排空分数和更低的SMARI变化。更大样本量的进一步研究，纳入不同并存情况和亚型的IBS患者，并结合结肠传输研究和胆囊射血分数评估可进一步为本研究提供更多意义。
