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Abstract：
OBJECTIVE: The aim of this study was to determine the prevalence of Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) among HPV-positive women undergoing colposcopy at the Second Xiangya Hospital of Central South University, Hunan, China. Additionally, we aimed to assess the impact of C. trachomatis or M. genitalium co-infection with HPV on the severity of cervical lesions.
METHODS: We collected HPV data, cervical cytology results, and demographic information from 439 women attending colposcopy. Cervical swabs were obtained for simultaneous amplification testing (SAT) of C. trachomatis and M. genitalium. Multivariate logistic regression analyses were performed to examine the association between sexually transmitted pathogens and cervical lesions.
RESULTS: Among the participants, C. trachomatis was detected in 17 (3.87%) individuals, and M. genitalium in 16 (3.64%) individuals. There was no co-infection of C. trachomatis and M. genitalium. The highest prevalence of M. genitalium was observed in women aged 19-30 years (10.20%; 95% CI, 1.41-18.99%), with a subsequent decline in prevalence with increasing age (Ptrend = 0.014). The most common HPV subtype in our study was HPV52 (30.79%), followed by HPV16 (18.62%), HPV58 (16.95%), and HPV53 (10.02%). Infection with HPV16 (OR = 3.43, 95% CI, 2.13-5.53), HPV31 (OR = 3.70, 95% CI, 1.44-9.50), and HPV33 (OR = 3.71, 95% CI, 1.43-9.67) was associated with an increased severity of cervical lesions, while HPV53 infection was not likely to lead to advanced cervical lesions (OR = 0.45, 95% CI, 0.23-0.89). The leukocyte level in vaginal secretions (P = 0.042) and cervical cytology results (P < 0.001) showed associations with the degree of cervical lesions. However, there was no significant association between C. trachomatis or M. genitalium infection and the severity of cervical lesions, nor with their co-infection with HPV16.
CONCLUSIONS: There was no correlation between co-infection of Chlamydia trachomatis or Mycoplasma genitalium and the degree of cervical lesions in HPV-positive population in Hunan, China. Our findings emphasized the need to pay more attention to M. genitalium infection among young women. Increased levels of leukocytes in vaginal secretions may be linked to cervical lesions. HPV16, HPV31, and HPV33 in Hunan province, China, may exhibit higher cervical pathogenicity.
METHODS: We collected HPV data, cervical cytology results, and demographic information from 439 women attending colposcopy. Cervical swabs were obtained for simultaneous amplification testing (SAT) of C. trachomatis and M. genitalium. Multivariate logistic regression analyses were performed to examine the association between sexually transmitted pathogens and cervical lesions.
RESULTS: Among the participants, C. trachomatis was detected in 17 (3.87%) individuals, and M. genitalium in 16 (3.64%) individuals. There was no co-infection of C. trachomatis and M. genitalium. The highest prevalence of M. genitalium was observed in women aged 19-30 years (10.20%; 95% CI, 1.41-18.99%), with a subsequent decline in prevalence with increasing age (Ptrend = 0.014). The most common HPV subtype in our study was HPV52 (30.79%), followed by HPV16 (18.62%), HPV58 (16.95%), and HPV53 (10.02%). Infection with HPV16 (OR = 3.43, 95% CI, 2.13-5.53), HPV31 (OR = 3.70, 95% CI, 1.44-9.50), and HPV33 (OR = 3.71, 95% CI, 1.43-9.67) was associated with an increased severity of cervical lesions, while HPV53 infection was not likely to lead to advanced cervical lesions (OR = 0.45, 95% CI, 0.23-0.89). The leukocyte level in vaginal secretions (P = 0.042) and cervical cytology results (P < 0.001) showed associations with the degree of cervical lesions. However, there was no significant association between C. trachomatis or M. genitalium infection and the severity of cervical lesions, nor with their co-infection with HPV16.
CONCLUSIONS: There was no correlation between co-infection of Chlamydia trachomatis or Mycoplasma genitalium and the degree of cervical lesions in HPV-positive population in Hunan, China. Our findings emphasized the need to pay more attention to M. genitalium infection among young women. Increased levels of leukocytes in vaginal secretions may be linked to cervical lesions. HPV16, HPV31, and HPV33 in Hunan province, China, may exhibit higher cervical pathogenicity.
摘要：
目的：本研究的目的是确定在中南大学湘雅二医院接受阴道镜检查的HPV阳性妇女中沙眼衣原体（CT）和生殖支原体（MG）的患病率。湖南,中国。此外,我们旨在评估沙眼衣原体或生殖分枝杆菌与HPV共感染对宫颈病变严重程度的影响.
方法：我们收集了HPV数据，宫颈细胞学结果,和439名接受阴道镜检查的女性的人口统计信息。获得宫颈拭子用于沙眼衣原体和生殖分枝杆菌的同时扩增测试(SAT)。进行了多因素logistic回归分析，以检查性传播病原体与宫颈病变之间的关系。
结果：在参与者中，沙眼衣原体检出17例(3.87%)，和生殖分枝杆菌16例（3.64%）。没有沙眼衣原体和生殖分枝杆菌的共感染。生殖器支原体的患病率最高的是19-30岁的女性（10.20％;95％CI，1.41-18.99％），随着年龄的增长，患病率随后下降（Ptrend=0.014）。我们研究中最常见的HPV亚型是HPV52（30.79％），其次是HPV16（18.62%），HPV58（16.95%），和HPV53（10.02%）。HPV16感染（OR=3.43，95％CI，2.13-5.53），HPV31（OR=3.70，95%CI，1.44-9.50），和HPV33（OR=3.71，95％CI，1.43-9.67）与宫颈病变严重程度增加有关，而HPV53感染不太可能导致晚期宫颈病变(OR=0.45,95%CI,0.23-0.89)。阴道分泌物中白细胞水平(P=0.042)和宫颈细胞学结果(P<0.001)与宫颈病变程度有关。然而,沙眼衣原体或生殖分枝杆菌感染与宫颈病变的严重程度之间没有显着关联，也没有与HPV16共感染。
结论：湖南地区HPV阳性人群中沙眼衣原体或生殖支原体合并感染与宫颈病变程度无相关性，中国。我们的发现强调需要更加关注年轻女性的生殖支原体感染。阴道分泌物中白细胞水平升高可能与宫颈病变有关。湖南省HPV16、HPV31和HPV33,中国,可能表现出更高的宫颈致病性。
方法：我们收集了HPV数据，宫颈细胞学结果,和439名接受阴道镜检查的女性的人口统计信息。获得宫颈拭子用于沙眼衣原体和生殖分枝杆菌的同时扩增测试(SAT)。进行了多因素logistic回归分析，以检查性传播病原体与宫颈病变之间的关系。
结果：在参与者中，沙眼衣原体检出17例(3.87%)，和生殖分枝杆菌16例（3.64%）。没有沙眼衣原体和生殖分枝杆菌的共感染。生殖器支原体的患病率最高的是19-30岁的女性（10.20％;95％CI，1.41-18.99％），随着年龄的增长，患病率随后下降（Ptrend=0.014）。我们研究中最常见的HPV亚型是HPV52（30.79％），其次是HPV16（18.62%），HPV58（16.95%），和HPV53（10.02%）。HPV16感染（OR=3.43，95％CI，2.13-5.53），HPV31（OR=3.70，95%CI，1.44-9.50），和HPV33（OR=3.71，95％CI，1.43-9.67）与宫颈病变严重程度增加有关，而HPV53感染不太可能导致晚期宫颈病变(OR=0.45,95%CI,0.23-0.89)。阴道分泌物中白细胞水平(P=0.042)和宫颈细胞学结果(P<0.001)与宫颈病变程度有关。然而,沙眼衣原体或生殖分枝杆菌感染与宫颈病变的严重程度之间没有显着关联，也没有与HPV16共感染。
结论：湖南地区HPV阳性人群中沙眼衣原体或生殖支原体合并感染与宫颈病变程度无相关性，中国。我们的发现强调需要更加关注年轻女性的生殖支原体感染。阴道分泌物中白细胞水平升高可能与宫颈病变有关。湖南省HPV16、HPV31和HPV33,中国,可能表现出更高的宫颈致病性。
