METHODS: This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model.
RESULTS: MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04-1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m2, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer.
CONCLUSIONS: Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.
方法:本研究招募了688名CRC患者和690名健康对照。MMP8多态性与CRC易感性之间的关系通过按年龄分层后计算比值比(OR)和95%置信区间(CI)来评估,性别,体重指数(BMI),吸烟,和多遗传模型下的饮酒。
结果:MMP8rs3740938与CRC易感性增加相关(p=0.016,OR=1.24,95%CI:1.04-1.48),特别是在年龄>60岁的受试者中检测到这种关联,女性,BMI>24kg/m2的人,吸烟者,和饮酒者。此外,发现rs3740938与直肠癌的病理类型有关。
结论:我们的结果首先显示MMP8中的rs3740938是CRC易感性的危险因素。这一发现可能为理解MMP8基因在CRC发病机制中的作用提供了新的生物学视角。