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Abstract：
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene polymorphism and CRC risk in the Chinese Han population.
METHODS: This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model.
RESULTS: MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04-1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m2, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer.
CONCLUSIONS: Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.
METHODS: This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model.
RESULTS: MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04-1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m2, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer.
CONCLUSIONS: Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.
摘要：
背景：结直肠癌（CRC）是最常见的恶性肿瘤之一，受临床表型中几个遗传基因座的影响。这项研究的目的是确定MMP8基因多态性与中国汉族人群CRC风险之间的关系。
方法：本研究招募了688名CRC患者和690名健康对照。MMP8多态性与CRC易感性之间的关系通过按年龄分层后计算比值比（OR）和95％置信区间（CI）来评估，性别,体重指数（BMI），吸烟,和多遗传模型下的饮酒。
结果：MMP8rs3740938与CRC易感性增加相关（p=0.016，OR=1.24，95％CI：1.04-1.48），特别是在年龄>60岁的受试者中检测到这种关联，女性,BMI>24kg/m2的人，吸烟者，和饮酒者。此外，发现rs3740938与直肠癌的病理类型有关。
结论：我们的结果首先显示MMP8中的rs3740938是CRC易感性的危险因素。这一发现可能为理解MMP8基因在CRC发病机制中的作用提供了新的生物学视角。
方法：本研究招募了688名CRC患者和690名健康对照。MMP8多态性与CRC易感性之间的关系通过按年龄分层后计算比值比（OR）和95％置信区间（CI）来评估，性别,体重指数（BMI），吸烟,和多遗传模型下的饮酒。
结果：MMP8rs3740938与CRC易感性增加相关（p=0.016，OR=1.24，95％CI：1.04-1.48），特别是在年龄>60岁的受试者中检测到这种关联，女性,BMI>24kg/m2的人，吸烟者，和饮酒者。此外，发现rs3740938与直肠癌的病理类型有关。
结论：我们的结果首先显示MMP8中的rs3740938是CRC易感性的危险因素。这一发现可能为理解MMP8基因在CRC发病机制中的作用提供了新的生物学视角。
