Abstract：
Atrial fibrillation (AF) is closely related to abnormal cerebral blood flow. Inflammation and oxidative stress have always been important factors in the pathophysiology of AF. It remains unknown whether inflammation and oxidative stress are correlated to hippocampal perfusion in patients with AF.Sixty-three patients with AF with normal hippocampal blood perfusion (NHBP) were compared to 71 patients with AF with abnormal hippocampal blood perfusion (AHBP) using a case-control study design. The serum levels of inflammation and oxidative stress were measured. The hippocampal perfusion was detected. (1) The serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and oxidized low-density lipoprotein (ox-LDL) were statistically higher in the AHBP group than in the NHBP group. In the AHBP subgroup analysis, the serum levels of hs-CRP and IL-6 were statistically higher in patients with persistent AF than those with paroxysmal AF. (2) The relative cerebral blood volume (rCBV), mean transit time (MTT), and the time-to-peak (TTP) were statistically higher in the AHBP group than in the NHBP group. Moreover, cerebral blood flow (rCBF) was statistically lower in the AHBP group than in the NHBP group. (3) relative cerebral blood volume (rCBV), rCBF, MTT, and TTP were passively associated with serum hs-CRP and IL-6; rCBV, rCBF, and MTT were positively associated with ox-LDL. The serum levels of hs-CRP, IL-6, and ox-LDL were associated with AHBP in patients with AF after multivariate logistic regression analysis.Oxidative stress and inflammatory biomarkers were increased in patients with AF with AHBP, in which the serum levels of hs-CRP and IL-6 in the persistent AF group were statistically higher than those in the paroxysmal AF group. The serum levels of hs-CRP, IL-6, and ox-LDL were associated with AHBP in patients with AF.
摘要：
心房颤动(AF)与脑血流异常密切相关。炎症和氧化应激一直是房颤病理生理过程中的重要因素。目前尚不清楚房颤患者的炎症和氧化应激是否与海马灌注相关。采用病例对照研究设计，将63例海马血液灌注（NHBP）正常的房颤患者与71例海马血液灌注异常（AHBP）的房颤患者进行了比较。检测血清炎症和氧化应激水平。检测海马灌注。(1)血清超敏C反应蛋白(hs-CRP)水平,白细胞介素6（IL-6），AHBP组的氧化低密度脂蛋白（ox-LDL）在统计学上高于NHBP组。在AHBP亚组分析中，持续性房颤患者血清hs-CRP和IL-6水平明显高于阵发性房颤患者。(2)相对脑血容量(rCBV),平均运输时间(MTT)，AHBP组的峰值时间（TTP）在统计学上高于NHBP组。此外，AHBP组的脑血流量（rCBF）在统计学上低于NHBP组。(3)相对脑血容量(rCBV),rCBF,MTT,和TTP与血清hs-CRP和IL-6被动相关；rCBV，rCBF,MTT与ox-LDL呈正相关。血清hs-CRP水平,多因素logistic回归分析显示,IL-6、ox-LDL与房颤患者AHBP相关。AHBP房颤患者氧化应激和炎症生物标志物增加，其中持续性房颤组血清hs-CRP和IL-6水平明显高于阵发性房颤组。血清hs-CRP水平,IL-6和ox-LDL与房颤患者的AHBP相关。
