Abstract：
Following the discovery of graphene, there has been a surge in exploring other two-dimensional (2D) nanocrystals, including MoS2. Over the past few decades, MoS2-based nanocrystals have shown great potential applications in biosensing, owing to their excellent physico-chemical properties. Unlike graphene, MoS2 shows layer-dependent finite band gaps (∼1.8 eV for a single layer and ∼1.2 for bulk) and relatively strong interaction with the electromagnetic spectrum. The tunability of the size, shape, and intrinsic properties, such as high optical absorption, electron mobility, mechanical strength and large surface area, of MoS2 nanocrystals, make them excellent alternative probe materials for preparing optical, photothermal, and electrical bio/immunosensors. In this review, we will provide insights into the rapid evolutions in bio/immunosensing applications based on MoS2 and its nanohybrids. We emphasized the various synthesis, characterization, and functionalization routes of 2D MoS2 nanosheets/nanoflakes. Finally, we discussed various fabrication techniques and the critical parameters, including the limit of detection (LOD), linear detection range, and sensitivity of the biosensors. In addition, the role of MoS2 in enhancing the performance of biosensors, the limitations associated with current biosensing technologies, future challenges, and clinical implications are addressed. The advantages/disadvantages of each biosensor technique are also summarized. Collectively, we believe that this review will encourage resolute researchers to follow up further with the state-of-the-art MoS2-based biosensing technology.
摘要：
随着石墨烯的发现，探索其他二维(2D)纳米晶体的热潮，包括MoS2.在过去的几十年里，基于MoS2的纳米晶体在生物传感中显示出巨大的潜在应用,由于其优异的物理化学性能。不像石墨烯,MoS2显示了与层相关的有限带隙（单层为1.8eV，体为1.2）和与电磁频谱的相对较强的相互作用。大小的可调性，形状,和内在属性，如高光吸收，电子迁移率，机械强度和大表面积，MoS2纳米晶体，使它们成为制备光学的优秀替代探针材料，光热,和电生物/免疫传感器。在这次审查中,我们将提供基于MoS2及其纳米杂种的生物/免疫传感应用的快速发展的见解。我们强调了各种综合，表征，和2DMoS2纳米片/纳米片的功能化路线。最后,我们讨论了各种制造技术和关键参数，包括检测限（LOD），线性检测范围,和生物传感器的灵敏度。此外,MoS2在增强生物传感器性能方面的作用，与当前生物传感技术相关的局限性，未来的挑战,并解决了临床意义。还总结了每种生物传感器技术的优缺点。总的来说，我们相信,这篇综述将鼓励坚定的研究人员进一步跟进最新的基于MoS2的生物传感技术.
