Abstract：
G1 to S phase transition 1 (GSPT1) is a key translation termination factor that significantly overexpressed in various cancer tissues and cells. Molecular glue is a kind of small molecule, which can bind to an E3 ligase such as cereblon (CRBN) and subsequently recruit neosubstrate proteins for ubiquitination-proteasomal degradation. This emerging therapeutic approach shows great potential in treating cancers and other diseases. This review aims to introduce current understanding of antitumor mechanism of molecular glues targeting GSPT1, summarize pharmacology profiles of existing molecular glues, and outline development strategies of novel molecular glues. The insights provided in this review will be valuable for future studies.
摘要：
G1至S期转变1(GSPT1)是在多种癌组织和细胞中显著过表达的关键翻译终止因子。分子胶是一种小分子,它可以与E3连接酶如cereblon（CRBN）结合，随后招募新底物蛋白进行泛素化-蛋白酶体降解。这种新兴的治疗方法在治疗癌症和其他疾病方面显示出巨大的潜力。本文旨在介绍目前对靶向GSPT1的分子胶抗肿瘤机制的认识，总结现有分子胶的药理学概况，并概述了新型分子胶的发展策略。这篇综述提供的见解将对未来的研究有价值。
